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Tablet Coating Agent

    Tablet coating agents

    Tablet coating agents are used to coat a tablet to protect against decomposition by atmospheric oxygen or humidity, to provide a desired release pattern, to mask taste or odor, or for aesthetic purposes. Coating may be sugar, film, or thick covering around a tablet. Sugar-coated tablets generally start to break up in the stomach. Film forms a thin cover around a formed tablet or bead. Unless it is enteric, film dissolves in the stomach. Enteric coating passes through the stomach to break up in the intestines. Some water-insoluble coatings (e.g., ethylcellulose) are used to slow the release of drug in the gastrointestinal tract.

    Sugar Coating

    • Liquid glucose
    • Sucrose

    Film coating

    • Hydroxyethyl cellulose
    • Hydroxypropyl cellulose
    • Hydroxypropyl methylcellulose
    • Methylcellulose (e.g., Methocel)
    • Ethylcellulose (e.g., Ethocel)

    Enteric coating

    • Cellulose acetate phthalate
    • Shellac (35% in alcohol, pharmaceutical glaze)

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