Classes
DAE Class; Rx
Common Brand Names; Zavzpret
- CGRP Receptor Antagonists
Description
Intranasal calcitonin gene-related peptide receptor antagonist
Used for the acute treatment of migraine with or without aura
Safety of treating more than 8 migraines/30 days not established
Indications
Indicated for acute treatment of migraine with or without aura
Contraindications
History of hypersensitivity to zavegepant or other ingredients
Adverse Effects
>10%
Taste disorder (18%)
1-10%
Nausea (4%)
Nasal discomfort (3%)
Vomiting (2%)
<1%
Hypersensitivity, including facial swelling and urticaria
Warnings
Hypersensitivity reactions reported, including facial swelling and urticaria; initiate appropriate therapy if hypersensitivity occurs
Ask patient to discuss prescription, OTC medications, or herbal supplements that they take or plan to take
Drug interaction overview
- Substrate of OATP1B3 and NTCP
OATP1B3 or NTCP inhibitors
- Avoid coadministration
- Inhibitors of organic anion transporting polypeptide 1B3 (OATP1B3) or sodium taurocholate cotransporting polypeptide (NTCP) transporters may significantly increase zavegepant exposure
OATP1B3 or NTCP inducers
- Avoid coadministration
- Inducers of OATP1B3 or NTCP transporters may decrease zavegepant exposure
Intranasal decongestants
- Dosage modification
- Avoid coadministration; if unavoidable, administer intranasal decongestants at least 1 hr after zavegepant
- Coadministration may decrease systemic exposure and efficacy of zavegepant
Pregnancy and Lactation
Pregnancy
Data are not available on developmental risk associated with the use in pregnant females
Lactation
Data are unavailable regarding the presence of zavegepant or its metabolites in human milk, effects on breastfed infants, or effects on milk production
Maximum Dosage
Adults
10 mg/day intranasally.
Geriatric
10 mg/day intranasally.
Adolescents
Safety and efficacy have not been established.
Children
Safety and efficacy have not been established.
Infants
Safety and efficacy have not been established.
Neonates
Safety and efficacy have not been established.
How supplied
Zavegepant
intranasal solution
- 10mg/spray