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    DEA Class;  Rx

    Common Brand Names; Trintellix

    •  Antidepressants, Other; 

    Oral antidepressant that is a serotonin modulator and stimulator
    Indicated for major depressive disorder in adults
    Increased risk of suicidality during the initial stages of treatment in pediatric and young adult patients

    Indicated for the treatment of major depression.

    Hypersensitivity to vortioxetine or any component of formulation

    • Nausea (21-32%)
    • Diarrhea (7-10%)
    • Dizziness (6-9%)
    • Dry mouth (6-8%)
    • Constipation (3-6%)
    • Vomiting (3-6%)
    • Flatulence (1-3%)
    • Pruritus (1-3%)
    • Abnormal dreams (<1-3%)
    • Weight gain
    • Acute pancreatitis
    • Angle closure glaucoma
    • Seizure
    • Rash, generalized rash
    • Difficulties in sexual desire, sexual performance, and sexual satisfaction
    • Aggression, agitation, anger, hostility, irritability

    May worsen mania symptoms or activate mania/hypomania in patients with bipolar disorder

    Risk of mydriasis; may trigger angle closure attack in patients with angle-closure glaucoma with anatomically narrow angles without a patent iridectomy

    Increases risk of hyponatremia and cognitive impairment especially in the elderly; hyponatremia can occur in association with the syndrome of inappropriate antidiuretic hormone secretion (SIADH); patients taking diuretics or who are otherwise volume-depleted can be at greater risk; consider discontinuation of drug in patients with symptomatic hyponatremia; appropriate medical intervention should be instituted

    Dosage reduction is recommended in patients known to be poor CYP2D6 metabolizers because these patients have higher vortioxetine plasma concentrations than extensive CYP2D6 metabolizers

    Limited human data available on use during pregnancy to inform any drug-associated risks

    There is no information regarding presence of vortioxetine in human milk, effects on the breastfed infant, or effects on milk production

    Present in rat milk


    20 mg/day PO.


    20 mg/day PO.


    Safety and efficacy have not been established.


    Safety and efficacy have not been established.


    Safety and efficacy have not been established.


    tablet, immediate-release

    • 5mg
    • 10mg
    • 20mg
    • NOTE: Former brand name Brintellix