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Vitamin E Polyethylene Glycol Succinate

    Synonyms: Speziol TPGS Pharma; tocofersolan; tocophersolan; tocopherol polyethylene glycol succinate; D-a-tocopheryl polyethylene glycol 1000 succinate; TPGS; vitamin E polyethylene glycol 1000 succinate; vitamin E TPGS; VEGS.

    Description: Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.

    Chemical Name: 4-O-(2-Hydroxyethyl)-1-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl]butanedioate

    Absorption enhancer; antioxidant; emulsifying agent; granulation aid; ointment base; solubilizing agent; surfactant; suspending agent; tablet binder.

    • Vitamin E polyethylene glycol succinate is an esterified vitamin E (tocopherol) derivative primarily used as a solubilizer or emulsifying agent because of its surfactant properties.

    • Structurally, it is amphipathic and hydrophilic, unlike the tocopherols, and therefore it is a water-soluble derivative that can be used in pharmaceutical formulations such as capsules, tablets, hot-melt extrusion, microemulsions, topical products, and parenterals.

    • One of the most important applications is its use as a vehicle for lipid-based drug delivery formulations. It can also be used as a source of vitamin E.

    • Vitamin E polyethylene glycol succinate has been characterized with respect to its mechanism of action and studied as a Pglycoprotein inhibitor.

    Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.

    Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240 mg vitamin E TPGS) per day.

    Observe normal precautions appropriate to the circumstances and quantity of the material handled. Gloves and eye protection are recommended.

    Alpha tocopherol.