Vinblastine Uses/Indications Dosage Side effects- Drugsdose

Classes

DEA Class; Rx

Common Brand Names; Velban

Antineoplastics, Vinca Alkaloid

Vinblastine is a member of the Vinca alkaloid antineoplastic agents; extracted from the periwinkle plant; similar to vincristine in action and structure, but the alkaloids significantly differ in toxicities and spectrum of activity; the dose-limiting toxicity of vinblastine is bone-marrow suppression.

Indications

Indicated for the treatment of breast cancer.

For the treatment of Langerhans’ cell histiocytosis.

For the treatment of Hodgkin lymphoma.

For the treatment of non-Hodgkin’s lymphoma (NHL).

For the treatment of testicular cancer or choriocarcinoma.

For the treatment of cutaneous T-cell lymphoma (CTCL) (aka mycosis fungoides).

For the treatment of Kaposi’s sarcoma.

For the treatment of bladder cancer.

Contraindications

Hypersensitivity

Intrathecal (IT) administration

Active bacterial infection

Myelosuppression

Adverse Effects

Anemia
Leukopenia
Myelosuppression
Alopecia
Peripheral neuropathy
Hypertension
Bronchospasm
Nausea
Vomiting
Anorexia
Diarrhea
Constipation
Paralytic ileus
Jaw pain
Aspermia
Amenorrhea

Warnings

Bone marrow depression, neuropathy, neuromuscular disease may occur

Caution when administering neurotoxic agents, ototoxic agents concomitantly

Caution in pulmonary disease, liver impairment, intestinal obstruction, paralytic ileus

Potential for jaw/parotid pain, hoarseness & dysphagia due to cranial neuropathy

Vesicant

Previous radiation treatment or chemotherapy

Avoid pregnancy

Pregnancy and Lactation

Pregnancy Category: D

Lactation: not known if excreted in breast milk, do not nurse

Maximum Dosage

Adults

18.5 mg/m2 IV administered in weekly intervals.

Elderly

18.5 mg/m2 IV administered in weekly intervals.

Adolescents

12.5 mg/m2/day IV administered weekly.

Children

12.5 mg/m2/day IV administered weekly.

How supplied

Vinblastine sulfate

injectable solution

1mg/mL

powder for injection

10mg