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Vecuronium

    Brands

    DEA Class;  Rx

    Common Brand Names; Norcuron

    •  Neuromuscular Blockers, Nondepolarizing
     

    Parenteral, intermediate-acting, nondepolarizing, neuromuscular blocking agent
    Used for an adjunct to general anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation
    Minimal catecholamine and histamine release

    Indicated For muscular relaxation during non-emergent endotracheal intubation.

    For muscular relaxation during non-emergent endotracheal intubation.

    For neuromuscular blockade during mechanical ventilation in intensive care patients.

    For neuromuscular blockade during surgery.

    For muscular relaxation during rapid-sequence intubation (RSI)

    For the prevention of shaking chills induced by therapeutic hypothermia after cardiac arrest.

    Hypersensitivity

    Lack of ventilatory support

    Neuromuscular disease

    • Skeletal muscle weakness or paralysis
    • Respiratory insufficiency or apnea
    • Hypersensitivity reactions associated with histamine release (e.g., bronchospasm, flushing, erythema, acute urticaria, hypotension, tachycardia)
    • Itching
    • Myositis ossificans (prolonged use)
    • Acute quadriplegic myopathy syndrome (prolonged use)
    • Less cardiovascular effects than pancuronium or atracurium

    Additive/synergistic effects if administered with or following an opioid, sedative or anesthetic agent

    Severe anaphylactic reactions to neuromuscular blocking agents have been reported; these reactions have, in some cases, been life threatening and fatal; because of the potential severity of these reactions, the necessary precautions, such as the immediate availability of appropriate emergency treatment, should be taken; neuromuscular cross-sensitivity with other nuromuscular blocking agents possible

    Some patients may experience prolonged recovery (paralysis) of neuromuscular function

    Adequate ventilatory support mandatory, may experience resistance with >25% TBSA burns, may experience increased sensitivity with electrolyte disorders (hyperMg, hypoK, hypoCa)

    CAUTION: Hepatobiliary obstruction, renal dysfunction will significantly prolong duration of action

    Pregnancy Category: C

    Lactation: Not known if excreted in breast milk; effect on nursing infant not known; used during pregnancy only when clearly needed

    Specific maximum dosage information is not available. Dosage must be individualized based on clinical response.

    Vecuronium Bromide

    powder for injection

    • 10mg
    • 20mg