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Trospium Chloride

    Brands

    DEA Class;  Rx

    Common Brand Names; Sanctura, Sanctura XR

    • Anticholinergics, Genitourinary
     

    Oral non-specific antimuscarinic agent
    Used for the treatment of overactive bladder (OAB) in adults
    Dry mouth and constipation may occur; limited potential for drug-drug interactions

    Indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urinary urgency, and urinary frequency, including neurogenic bladder.

    Urinary/gastric retention

    Uncontrolled narrow-angle glaucoma

    Hypersensitivity

    • Dry mouth (20.1%)
    • Constipation (9.6%)
    • Tachycardia (<2%)
    • Headache (4.2%)
    • Fatigue (1.9%)
    • Rash (<2%)
    • Dyspepsia (1-2%)
    • Abdominal pain (1-3%)
    • Abdominal distention (<2%)
    • Constipation (9-10%)
    • Dry eyes (1-2%)
    • Dyspepsia (1-2%)
    • Flatulence (1-2%)
    • Urinary retention (<1%)
    • Urinary tract infection (1-7%)
    • Nasopharyngitis (3%)
    • Nasal dryness (1%)

    Use caution in renal impairment, geriatric patients, moderate or severe hepatic dysfunction

    Angioedema of the face, lips, tongue and/or larynx reported (including with 1st dose); if involvement of the tongue, hypopharynx, or larynx occurs promptly discontinue; promptly provide appropriate therapy and/or measures necessary to ensure a patent airway function

    Administer with caution to patients with clinically significant bladder outflow obstruction or gastrointestinal obstructive disorders due to risk of urinary or gastric retention; use with caution in patients with conditions such as ulcerative colitis, intestinal atony, and myasthenia gravis

    To administer, must carefully monitor patients with controlled narrow-angle glaucoma; benefits should outweigh risks

    Somnolence reported; advise patients not to drive or operate heavy machinery until they know how therapy affects them

    Pregnancy Category: C

    Lactation: Excretion in milk unknown; use with caution

    Adults

    60 mg/day PO.

    Elderly

    60 mg/day PO.

    Adolescents

    Maximum dosage is not well-defined.

    Children

    Maximum dosage is not well-defined.

    Trospium Chloride

    tablet

    • 20mg

    capsule, extended release

    • 60mg