Classes
DEA Class; Rx
Common Brand Names; Artane, Trihex
- Antiparkinson Agents, Anticholinergics
Description
An oral synthetic, tertiary antimuscarinic that penetrates the central nervous system (CNS)
Indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic); often useful as adjuvant therapy with levodopa
Also helps control of extrapyramidal disorders due to CNS drugs (e.g., phenothiazines, thioxanthenes, and butyrophenones)
Indications
Indicated for the treatment of idiopathic parkinsonism or Parkinson’s disease.
For the treatment of drug-induced extrapyramidal symptoms
For the treatment of clozapine-induced sialorrhea† (drooling).
Contraindications
Hypersensitivity
Angle-closure glaucoma
Adverse Effects
- Anticholinergic side effects (30-50%)
- Rash
- Suppurative parotitis
- Hallucination
- Paralytic ileus
Warnings
Exacerbation of parkinsonism, neuroleptic malignant syndrome, and withdrawal symptoms associated with therapy discontinuation or dose reduction; drug should be withdrawn gradually
Perform gonioscope evaluation before initiating treatment; monitor intraocular pressure closely at regular periodic intervals
Therapy may impair memory and exacerbate cognitive deficits in the elderly; may also cause delirium, hallucinations, and confusion when administered at high doses
Use extreme caution and monitor closely patients with liver, cardiac, kidney disorders, prostatic hyperplasia (urinary stricture), or with hypertension
Pregnancy and Lactation
Pregnancy Category: C
Lactation: no data; may inhibit lactation
Maximum Dosage
15 mg/day PO.
15 mg/day PO.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Trihexyphenidyl hydrochloride
tablets
- 2mg
- 5mg
elixir
- 0.4mg/mL