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Trifluridine

    Brands

    DEA Class; Rx

    Common Brand Names; Viroptic (DSC)

    • Antivirals, Ophthalmic

    Ophthalmic antiviral preparation with activity against herpes simplex virus (HSV) types 1 and 2, vaccinia virus, and some adenovirus strains; used for primary keratoconjunctivitis and recurrent epithelial keratitis due HSV types 1 and 2; used for epithelial keratitis that has not responded to idoxuridine or vidarabine.

    Indicated for the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2

    Hypersensitivity

    • Transient burning/stinging
    • Palpebral edema
    • Superficial punctate keratopathy
    • Epithelial keratopathy
    • Stromal edema
    • Keratitis sicca
    • Hyperemia
    • Increased IOP
    • Hypersensitivity reactions

    Cosnider other Tx if no improvement after 7 days or incomplete reepithelialization after 14 days

    Use >21 days should be avoided because of potential ocular toxicity

    Inactive against bacteria, fungi & Chlamydia

    Pregnancy Category: C

    Lactation: unlikely to be distributed into breast milk; use caution

    Adults

    9 drops/day to affected eye(s).

    Elderly

    9 drops/day to affected eye(s).

    Adolescents

    9 drops/day to affected eye(s).

    Children

    > = 6 years: 9 drops/day to affected eye(s).
    < 6 years: Safety and efficacy have not been established.

    Trifluridine

    ophthalmic solution

    • 1% (generic)