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Triamcinolone/Nystatin

    Brands

    Triamcinolone acetonide injectable suspension/nystatin

    DEA Class; Rx

    Common Brand Names; MyCo-Triacet II, Mycolog II, Mycogen II, Mytrex, Tri-Statin II

    • Antifungal/Corticosteroid Topicals

    Nystatin and triamcinolone are used together topically for short-term (< 2 weeks) treatment of candidal skin infections. Nystatin is an antifungal agent and triamcinolone is a corticosteroid used for its antiinflammatory, vasoconstrictive, and antipruritic properties. Compared to nystatin or triamcinolone alone, the combination has been shown to provide faster and more pronounced clearing of erythema and pruritus, especially in the first few days of treatment.

    Indicated for the short-term (i.e., less than 2 weeks) treatment of inflammatory cutaneous candidiasis caused by Candida albicans and other Candida sp..

    Hypersensitivity

    • Blistering
    • Burning
    • Dryness
    • Acniform eruptions
    • Excessive discoloring of the skin
    • Excessive hair growth (especially on face)
    • Hair loss (especially on scalp)
    • Inflammation around the mouth
    • Inflammation of hair follicles
    • Irritation
    • Itching
    • Peeling
    • Prickly heat
    • Striae
    • Secondary infection
    • Skin inflammation
    • Softening of the skin
    • Stretch marks
    • Stretching or thinning of the skin

    For topical use only

    Not for ophthalmic use

    Avoid contact with eyes

    Patient should report any signs of adverse reactions

    Systemic absorption of topical corticosteroids has produced reversible hypothalmic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria in some patients

    Conditions that augment systemic absorption include application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings

    Patients receiving a large dose of any potent topical steroid applied to a large surface area should be evaluated periodically for evidence of HPA axis suppression by using urinary free cortisol and ACTH stimulation tests, and for impairment of thermal homeostasis; if HPA axis suppression or elevation of body temperature occurs, make attempt to withdraw drug, reduce frequency of application, or substitute for less potent steroid

    Recovery of HPA axis function and thermal homeostasis are generally prompt and complete upon discontinuation of drug; infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids

    Children may absorb proportionally larger amounts of topical corticosteroids and thus may be more susceptible to systemic toxicity

    If irritation or hypersensitivity develops with combination of nystatin and triamcinolone acetonide, discontinue treatment and institute appropriate therapy

    Pregnancy Category: unknown

    Lactation: unknown if excreted in breast milk

    Adults

    No maximum dosage information is available.

    Elderly

    No maximum dosage information is available.

    Adolescents

    No maximum dosage information is available.

    Children

    No maximum dosage information is available.

    Triamcinolone/nystatin

    topical cream/ointment

    • (0.1%/100,000units)/g