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Tolterodine

    Brands

    DEA Class;  Rx

    Common Brand Names; Detrol, Detrol LA

    • Anticholinergics, Genitourinary
     

    Oral competitive selective antimuscarinic agent; reduces incontinence episodes and urinary urgency
    Used for treatment of overactive bladder (OAB) in adults; used as monotherapy or in combination with a beta-3 adrenoreceptor agonist if needed
    Extensive study in elderly

    Indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urinary urgency, and urinary frequency.

    Urinary or gastric retention

    Uncontrolled narrow-angle glaucoma

    Hypersensitivity to drug or ingredients or to fesoterodine fumarate, which is metabolized to 5-hydroxymethyl tolterodine

    • Dry mouth (40%)
    • Blurred vision
    • Constipation
    • Dizziness
    • Drowsiness
    • Dyspepsia
    • Headache
    • Xerophthalmia

    Controlled narrow-angle glaucoma, hepatic, or renal impairment

    Anaphylaxis and angioedema necessitating hospitalization and emergency treatment reported with first or subsequent doses; discontinue immediately if angioedema and hypotension, difficulty breathing, or airway obstruction develop

    Anticholinergic central nervous system effects (eg, dizziness, somnolence) reported; patients should not drive or operate heavy machinery until they adjust to therapy

    Use with caution in patients with myasthenia gravis, which is characterized by decreased cholinergic activity at neuromuscular junction

    When coadministered with strong CYP3A4 inhibitors, tolterodine should be given at reduced dosage

    There are no available data with use in pregnant women to inform drug-associated risks

    There is no information on presence in human milk, effects on breastfed infant, or on milk production; based on limited data, tolterodine is excreted into milk in mice in low amounts

    Adults

    4 mg/day PO.

    Geriatric

    4 mg/day PO.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Tolterodine tartrate

    tablet, immediate release

    • 1mg
    • 2mg

    capsule, extended release

    • 2mg
    • 4mg