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KAPS exam sample Material Test 1 Paper 2

    This KAPS Quiz contains older questions to help you practise. These questions are no longer used, but they’ll help you understand:

    • the types of content covered in each paper of the exam
    • how questions might be presented

    If you want to practise the sample papers under exam conditions, you’ll need to answer all 100 questions in each paper in 2 hours.

    KAPS Exam scoring

    You must complete all questions in the paper or papers you sit.

    To pass the exam, you need a mark of at least 50% in all subsections of the exam.

    Paper 1Pharmaceutical chemistry 50%
    Pharmacology and physiology 50%
    Paper 2Pharmaceutics 50%
    Therapeutics 50%

    Here is the Test 1 Paper 2

    Section 1 = 30 Questions

    Section 2 = 70 Questions

    Section 1

    Small changes in dose may lead to disproportionate increases in blood levels of

    Correct! Wrong!

    If a fixed dose of a drug that is eliminated by first order kinetics is administered intravenously at regular intervals, the time required to achieve a steady state plasma level depends only on the

    Correct! Wrong!

    A basic principle of drug absorption is that a drug is usually NOT absorbed

    Correct! Wrong!

    The system which is composed of a liquid dispersed in a liquid is

    Correct! Wrong!

    Which of the following characteristics is CORRECT for cationic aqueous creams?

    Correct! Wrong!

    Which of the following drugs is NOT absorbed systemically when given by mouth?

    Correct! Wrong!

    Occlusive dressings are used clinically with topical corticosteroids to

    Correct! Wrong!

    If a drug has a very small volume of distribution (Vd), it is likely that this drug

    Correct! Wrong!

    The route of drug administration that will give the MOST rapid onset of the pharmacologic effect is

    Correct! Wrong!

    The bioequivalence of two tablets containing an identical amount of the same drug manufactured by different companies is best determined by measuring

    Correct! Wrong!

    Thiopentone is of shorter duration of action than phenobarbitone because thiopentone

    Correct! Wrong!

    Which of the following is NOT administered as a racemic mixture?

    Correct! Wrong!

    Drugs that demonstrate non-linear pharmacokinetics show which of the following properties?

    Correct! Wrong!

    It was determined that 95% of an oral 80-mg dose of verapamil was absorbed in a 70 kg test subject. However, because of extensive biotransformation during its first pass through the portal circulation, the bioavailability of verapamil was only 25%. Assuming a liver blood flow of 1500 mL/min, the hepatic clearance of verapamil in this situation was:

    Correct! Wrong!

    A new cardiac glycoside has been developed for oral and intravenous (IV) administration. The drug has an elimination half-life of 24 hours and an apparent volume of distribution (Vd) of 3 L/kg.The effective drug concentration in plasma is 1.5 ng/mL. Toxic effects of the drug are observed at drug concentrations above 4 ng/mL. The drug is 75% bioavailable after an oral dose.Calculate an oral maintenance dose to be given once a day for a 65 kg male patient (age 68 years) with congestive heart failure and normal renal function. The aim is to achieve an average plasma concentration of 1.5 ng/mL. The dose should be

    Correct! Wrong!

    Salicylic acid has a pKa of 3.0 and undergoes significant renal tubular reabsorption. In aspirin overdose the renal clearance of salicylic acid will be increased to the greatest extent by

    Correct! Wrong!

    Which of the following drugs has the longest half-life?

    Correct! Wrong!

    The most common bacterial genus associated with acne vulgaris is

    Correct! Wrong!

    Which of the following microbes will NOT be covered by clindamycin?

    Correct! Wrong!

    The five antibody classes are

    Correct! Wrong!

    Which of the following statements is FALSE in regards to the use of combination antiinfective therapy?

    Correct! Wrong!

    Which of the following regimens is appropriate for managing herpes simplex encephalitis?

    Correct! Wrong!

    All of the following are official pharmacopoeial testing procedures for tablets EXCEPT

    Correct! Wrong!

    An example of an osmotic laxative is

    Correct! Wrong!

    A suspension is NOT a suitable dosage form for what type of injection?

    Correct! Wrong!

    Insulin preparations are usually administered by

    Correct! Wrong!

    Methylcellulose and similar agents are MOST commonly used in ophthalmic solutions to

    Correct! Wrong!

    In which base should hydrocortisone acetate be incorporated to give maximal topical absorption?

    Correct! Wrong!

    The term "impalpable" refers to a substance that is

    Correct! Wrong!

    Sodium metabisulphite is used as

    Correct! Wrong!

    The KAPS (Knowledge Assessment of Pharmaceutical Sciences) Exam Tests 1 Paper 2 Section 1
    Result
    Paper 2 Section 1 Pharmaceutics Passing Score 50%FAIL
    Result
    Paper 2 Section 1 Pharmaceutics Passing Score 50%Pass

    Section 2

    Data obtained from two different batches of tablets of a new hypoglycaemic agent undergoing clinical trial revealed that Batch 1 contains 200 mg of the drug and has an absolute bioavailability of 55%.Batch 2 contains 200 mg of the drug and relative to the first batch has a bioavailability of 165%What is the absolute bioavailability of the second batch?

    Correct! Wrong!

    How much ichthammol would be required to be added to a 5% w/w ichthammol in yellow soft paraffin ointment to prepare 200 g of a 17.5% w/w ichthammol in yellow soft paraffin ointment?

    Correct! Wrong!

    How many grams of chlorbutol are required to make 500 mL of an aqueous solution of such a concentration that 25 mL diluted to 100 mL with water will give a 1:2000 solution?

    Correct! Wrong!

    Dopamine 200 mg in 500 mL of normal saline at 5 μg/kg/min is ordered for a 70 kg patient. At what rate (mL/min) should the solution be infused to deliver the desired dose of 5 μg/kg/min?

    Correct! Wrong!

    Lignocaine hydrochloride is available for intravenous injection as a 2% solution packed in 5 mL disposable syringes. The dose is 1 mg per kg of body weight by slow intravenous injection.The volume of solution that should be used for a patient weighing 60 kg is

    Correct! Wrong!

    A solution with a concentration of 0.0125 % may also be described as containing

    Correct! Wrong!

    Lugol's Solution contains 5% of iodine, and the usual dose of the solution is 0.3 mL three times a day. The amount of iodine contained in the daily dose of the solution is

    Correct! Wrong!

    An infusion solution of sodium chloride 0.9% contains a sodium ion concentration of

    Correct! Wrong!

    A pharmacist has to prepare an aqueous solution containing 1 g of benzalkonium chloride in 2 L, by diluting a 10% solution. How many mL of water will be required?

    Correct! Wrong!

    The normal daily adult oral dose of celecoxib is within the range

    Correct! Wrong!

    Which of the following β-adrenergic blockers is predominantly renally cleared?

    Correct! Wrong!

    Dose levels of vancomycin should be reduced in patients suffering from

    Correct! Wrong!

    The normal adult daily dose of hydrochlorothiazide is within the range

    Correct! Wrong!

    For ongoing control of seizures phenytoin may be administered

    Correct! Wrong!

    Which of the following drugs should NOT be added to the therapy of a poorly controlled diabetic patient already on maximum doses of metformin and glibenclamide?

    Correct! Wrong!

    Which of the following medicines is NOT safe to use in children under 12 years of age?

    Correct! Wrong!

    Naloxone

    Correct! Wrong!

    Sodium Chloride 0.9% is a good wound cleansing agent for the following reasons EXCEPT it

    Correct! Wrong!

    Which one of the following statements relating to carbamazepine is FALSE?

    Correct! Wrong!

    Mr Earl, a patient with congestive heart failure, has been taking digoxin 125 mcg/day for one month and has a plasma digoxin concentration of 0.5 mcg/L(The therapeutic range for digoxin in patients with congestive heart failure is 0.5-0.8 mcg/L.)Mr Earl is not showing adequate clinical improvement. The MOST appropriate course of action is to

    Correct! Wrong!

    Mood disorders are being more widely managed with anticonvulsants. Which of the following is FALSE with regard to anticonvulsants used in this fashion?

    Correct! Wrong!

    When considering the usefulness of metformin monotherapy for a patient with type 2 diabetes mellitus, relevant patient factors to consider include

    Correct! Wrong!

    When monitoring anticoagulation with heparin, which of the following does NOT apply?

    Correct! Wrong!

    The Mantoux test uses

    Correct! Wrong!

    Which of the following is NOT true of methadone?

    Correct! Wrong!

    Interferons are indicated in which of the following conditions?

    Correct! Wrong!

    Which of the following compounds is unlikely to contribute to serotonin syndrome?

    Correct! Wrong!

    A 75-year-old male, with carcinoma of the prostate with local metastatasis, would be best treated with which of the following?

    Correct! Wrong!

    Metoclopramide is often given together with oral aspirin for the treatment of acutemigraine attacks. The rationale behind the use of metoclopramide is that it will

    Correct! Wrong!

    Which of the following drugs has been associated with interstitial pulmonary fibrosis?

    Correct! Wrong!

    Methysergide, when used for the prophylaxis of migraine

    Correct! Wrong!

    Cationic exchange resins are most commonly used to treat

    Correct! Wrong!

    Which of the following procedures should be used to monitor effective enoxaparin doses?

    Correct! Wrong!

    The following drugs can cause syndrome of inappropriate anti diuretic hormone (SIADH) EXCEPT

    Correct! Wrong!

    Chronic phenytoin therapy has been associated with

    Correct! Wrong!

    Which of the following properties is NOT true of indomethacin?

    Correct! Wrong!

    Which one of the following antipsychotic agents provides the lowest risk of extrapyramidal side effects?

    Correct! Wrong!

    Which of the following is contraindicated in nursing mothers because it inhibits milk production?

    Correct! Wrong!

    A 47-year-old premenopausal female with endometriosis is treated with danazol. Which of the following adverse effects is associated with danazol?

    Correct! Wrong!

    The most prevalent side effect of the chronic use of aluminium hydroxide gel is

    Correct! Wrong!

    Which of the following is a common sign of digoxin toxicity?

    Correct! Wrong!

    Sensitisation to sunlight may be produced in a patient being treated with

    Correct! Wrong!

    A common anticholinergic (atropine-like) side-effect of many drugs is

    Correct! Wrong!

    The use of pethidine in the management of chronic pain is discouraged because it

    Correct! Wrong!

    Halothane

    Correct! Wrong!

    Which of the following has been shown to be teratogenic?

    Correct! Wrong!

    Moclobemide is useful in Parkinson's disease because it inhibits

    Correct! Wrong!

    Which of the following has been shown to cause syndrome of inappropriate antidiuretic hormone release (SIADH)?

    Correct! Wrong!

    Which of the following is associated with lethargy, nightmares and cold extremities as side effects?

    Correct! Wrong!

    The following medicines have been reported to cause asthma attacks in susceptible people EXCEPT

    Correct! Wrong!

    Amiodarone may cause all of the following EXCEPT

    Correct! Wrong!

    The following drugs can cause an increase in the plasma concentration of digoxin with increased risk of toxicity EXCEPT

    Correct! Wrong!

    Food containing tyramine should NOT be part of the diet of patients taking which of the following antidepressants?

    Correct! Wrong!

    Theophylline has a very narrow therapeutic index. This drug has severe dose related toxicity (seizures and arrhythmias) which may occur without preceding milder symptoms of toxicity (vomiting and diarrhoea).Theophylline concentrations are raised by a number of commonly used drugs. Three such drugs are

    Correct! Wrong!

    Which of the following compounds may increase the effects of warfarin?

    Correct! Wrong!

    Which or the following oral antibiotics should not be taken at the same time as oral iron (Fe2+) containing products?

    Correct! Wrong!

    If a patient stabilised on digoxin is then administered amiodarone

    Correct! Wrong!

    The following points should be included in your counselling advice to a person using topical sunscreen agents to prevent sunburn EXCEPT

    Correct! Wrong!

    The preferred thyroid preparation for maintenance replacement therapy is which of the following drugs?

    Correct! Wrong!

    Single daily doses of simvastatin are best taken at

    Correct! Wrong!

    When dispensing a prescription for sucralfate the pharmacist should tell the patient that

    Correct! Wrong!

    Which of the following anticonvulsants is included in pregnancy Category D?

    Correct! Wrong!

    A patient with a superficial wound asks what time period is recommended between tetanus immunisations?

    Please select 2 correct answers

    Correct! Wrong!

    Time to peak effect of salmeterol is

    Correct! Wrong!

    In Parkinson's disease which of the following drugs is contraindicated?

    Correct! Wrong!

    Which of the following adverse effects could be seen with hydrochlorothiazide?

    Drugs ace test 1 paper 2 section 2 1
    Correct! Wrong!

    Each Slow-K dosage unit contains 8 mmoL of potassium as potassium chloride. How many mg of potassium chloride are in each Slow-K tablet? [Atomic Weight K = 39, Cl = 35]

    Drugs ace test 1 paper 2 section 2 1
    Correct! Wrong!

    Which of the following agents is MOST similar to hydrochlorothiazide?

    Drugs ace test 1 paper 2 section 2 1
    Correct! Wrong!

    When captopril is added to Ms Williams’ regimen, there is an increased likelihood of

    Drugs ace test 1 paper 2 section 2 1
    Correct! Wrong!

    Captopril is MOST similar in action to

    Drugs ace test 1 paper 2 section 2 1
    Correct! Wrong!

    The KAPS (Knowledge Assessment of Pharmaceutical Sciences) Exam Tests 1 Paper 2 Section 2
    Result
    Paper 2 Section 1 Pharmaceutics Passing Score 50%FAIL
    Result
    Paper 2 Section 1 Pharmaceutics Passing Score 50%Pass

    KAPS Exam Guide 

    Sample Test 1

    Paper 1

    Paper 2

    Sample Test 2

    Paper 1

    Paper 2

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