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Sulfadiazine

    Generic Only

    DEA Class; Rx

    Common Brand Names; 

    • Sulfonamides

    Exerts bacteriostatic action through competitive antagonism with para-aminobenzoic acid (PABA). Microorganisms that require exogenous folic acid and do not synthesize folic acid are not susceptible to the action of sulfonamides

    Indicated for

    • Prophylaxis of Recurrent Rheumatic Fever
    • Asymptomatic meningococcal 

    Other Indications & Uses

    Burkholderia pseudomallei, Chlamydia trachomatis,Nocardia asteroides & brasiliensis, Mycobacterium smegmatis, Mycobacterium chelonae, Mycobacterium fortuitum

    First Line:Mycobacterium smegmatis, Nocardia asteroides & brasiliensis

    Should not be used for group A beta-hemolytic strep infections

    Documented megaloblastic or folate deficiency anemia, obstructive uropathy

    • Diarrhea (33%)
    • Headache (33%)
    • Reversible oligospermia (33%)
    • Anorexia
    • Gastric distress
    • Nausea
    • Photosensitivity
    • Vomiting
    • Allergic reactions-rash
    • Aplastic anemia
    • Dizziness
    • Hypersensitivity
    • Itching
    • Thyroid fuction disturbance
    • Franulocytopenia
    • Thrombocytopenia

    Drink 250 mL water w/ each dose & frequently throughout day while taking sulfadiazine

    Adverse Drug Reactions

    Lyell’s syndrome, stevens Johnson syndrome, itching, rash, photosensitivity, thyroid function disturbance, anorexia, diarrhea, nausea, vomiting, dizziness, fever, headache, aplastic anemia, granulocytopenia, hemolytic anemia, leukopenia, thrombocytopenia, hepatitis, jaundice, hematuria, acute nephropathy, intestinal nephritis

    Pregnancy Category: C

    Lactation: enters breast milk; risk of kernicterus if infant <2 mo

    Adults

    Load

    2-4 g PO

    Maintenance

    2-4 g/day divided 3-6x/day PO

    Prophylaxis of Recurrent Rheumatic Fever

    >30 kg: 1 g/day

    <30 kg: 500 mg/day

    Sulfadiazine

    tablet

    • 500mg