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    DAE Class; Rx


    • Macrolides

    Spiramycin is antibiotic and is used to treat a large variety of bacterial infections, such as respiratory tract infections, middle ear infections, skin infections and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Spiramycin is important to take the drug for the full time period as prescribed, discontinuation of the drug may result in ineffective treatment.

    Spiramycin is primarily indicated in conditions like Depression, Menopausal symptoms, Nerve weakness, and can also be given in adjunctive therapy as an alternative drug of choice in Fibromyalgia.

    Spiramycin is contraindicated in conditions like Hypersensitivity to any component of product.

    The severe or irreversible adverse effects of Spiramycin, which give rise to further complications include Angioedema, Urticaria, Paresthesia, Colitis.

    Spiramycin produces potentially life-threatening effects which include Neuromuscular blockage, Ventricular arrhythmias. which are responsible for the discontinuation of Spiramycin therapy.

    The signs and symptoms that are produced after the acute overdosage of Spiramycin include Abdominal pain, Arrhythmias, Headache, Nausea & vomiting.

    The symptomatic adverse reactions produced by Spiramycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Anaphylactic shock.

    Antibiotic-associated colitis has been reported with use of spiramycin. Observe for superinfections. Rare hepatic impairment with or without jaundice has occurred with macrolides, it may be accompanied by malaise, nausea, vomiting, abdominal colic, and fever, discontinue use if these occur.

    Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.

    Drug should not be given to Pregnant Mothers, and Neonates.

    Toxoplasmosis, Cryptosporidiosis, Protozoal infections, Susceptible infections

    Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections.

    Cryptosporidiosis, Protozoal infections, Susceptible infections, Toxoplasmosis

    Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.
    Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid.


    Tabs: 1 g, 500 mg