Spectinomycin

DAE Class; Rx

Common Brand Names; TROBICIN

• Other Antibiotics

Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. Spectinomycin (HCl) is structurally related to aminoglycosides. Spectinomycin lacks amino sugar and glycosidic bonds. Spectinomycin has moderate antibacterial activity against many gram positive and gram negative bacteria but Spectinomycin (HCl) is especially effective against Niesseria gonorrhoeae. Antibiotics require constant drug level in body for therapeutic effect. This is achieveD by taking the medication at regular intervals of time throughout the day and night as prescribed. Spectinomycin (HCl) is important to take the drug for the full time period as prescribed, discontinuation of the therapy may result in ineffective treatment.

Spectinomycin (HCl) is primarily indicated in conditions like Cervicitits, Gonorrhoea, Proctitis, Urethritis.

Spectinomycin (HCl) is contraindicated in conditions like Pharyngeal gonorrhoea, Complicated gonococcal infection.

Patients receiving spectinomycin for gonorrhea should be tested for syphilis at the time of treatment and 3 months later because the symptoms of syphilis may be masked or delayed by treatment with spectinomycin. Spectinomycin should be used with caution during pregnancy and in the breast feeding mother. Spectinomycin should be used with caution in children because safe use has not been fully established. Spectinomycin reconstituted with bacteriostatic water containing benzyl alcohol should not be administered to neonates. CNS toxicity in neonates and infants has been blamed on inadvertent administration of benzyl alcohol.

Drug should not be given to Pregnant Mothers, and Neonates.

Adult: 2 g as a single dose. In cases whereby antibiotic resistance is prevalent, 4 g (10 mL) may be given but divided as two 5 mL inj, admin to 2 different inj sites.
Child: Beyond newborn period and <45 kg: 40 mg/kg as a single dose. Max: 2 g.

Spectinomycin