Soybean Oil

Synonyms: Aceite de soja; Calchem IVO-114; Lipex 107; Lipex 200; Shogun CT; soiae oleum raffinatum; soja bean oil; soyabean oil; soya bean oil.

Description: Soybean oil is a clear, pale-yellow colored, odorless or almost odorless liquid, with a bland taste that solidifies between 10 and 16C.

Chemical Name: Soybean oil

Oleaginous vehicle; solvent.

• In pharmaceutical preparations, soybean oil emulsions are primarily used as a fat source in total parenteral nutrition (TPN) regimens.

• Although other oils, such as peanut oil, have been used for this purpose, soybean oil is now preferred because it is associated with fewer adverse reactions.

• Emulsions containing soybean oil have also been used as vehicles for the oral and intravenous administration of drugs; drug substances that have been incorporated into such emulsions include amphotericin, diazepam, retinoids, vitamins, poorly water-soluble steroids, fluorocarbons, ibuprofen, and insulin.

• In addition, soybean oil has been used in the formulation of many drug delivery systems such as liposomes, microspheres, dry emulsions, self-emulsifying systems, microemulsions, nanoemulsions and nanocapsules, solid-in-oil suspensions, and multiple emulsions.

• Soybean oil may also be used in cosmetics and is consumed as an edible oil.
• As soybean oil has emollient properties, it is used as a bath additive in the treatment of dry skin conditions.

Soybean oil emulsions have been reported to be incompatible at 25C with a number of materials including calcium chloride, calcium gluconate, magnesium chloride, phenytoin sodium, and tetracycline hydrochloride.

Lower concentrations of these materials, or lower storage temperatures, may result in improved compatibility.

The source of the material may also affect compatibility; for example, while one injection from a particular manufacturer might be incompatible with a fat emulsion, an injection with the same amount of active drug substance from another manufacturer might be compatible.

Soybean oil is widely used intramuscularly as a drug vehicle or as a component of emulsions used in parenteral nutrition regimens; it is also consumed as an edible oil. Generally, soybean oil is regarded as an essentially nontoxic and nonirritant material. However, serious adverse reactions to soybean oil emulsions administered parenterally have been reported. These include cases of hypersensitivity, CNS reactions, and fat embolism. Interference with the anticoagulant effect of warfarin has also been reported.

Observe normal precautions appropriate to the circumstances and quantity of material handled. Spillages of soybean oil are slippery and should be covered with an inert absorbent material prior to disposal.

Canola oil; corn oil; cottonseed oil; peanut oil; sesame oil; sunflower oil.