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Sodium Stibogluconate

    Brands

    DEA Class; Rx

    Common Brand Names; Pentostam, stibogluconate sodium

    • Antileishmaniasis Agents

    Reduction in the fructose diphosphate and an inhibition of glycolysis

    Indicated for the treatment of Leishmaniasis (Orphan)

    Orphan designation for treatment of acute myeloid leukemia (AML)

    Hypersensitivity

    Significant renal impairment; breast-feeding

    • Anorexia
    • Nausea/vomiting
    • Abdominal pain
    • ECG changes
    • Headache
    • Lethargy
    • Myalgia
    • Raised liver enzymes
    • Coughing and substernal pain
    • Anaphylaxis (rare)
    • Fever
    • Sweating
    • Flushing
    • Vertigo
    • Bleeding from nose or gum
    • Jaundice
    • Rash
    • Pain and thrombosis on intravenous administration, intramuscular injection also painful

    —

    Pregnancy Category: unknown

    Lactation: unknown

    20 mg Sb/kg/day (maximum 850 mg) IV/IM for 20-28 days  

    Sodium stibogluconate

    injectable solution

    • 100mg Sb/mL