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Sodium Hyaluronate

    Synonyms: Hyaluronan; hyaluronate sodium; natrii hyaluronas; RITA HA C1-C.

    Description: The PhEur 6.3 describes sodium hyaluronate as the sodium salt of hyaluronic acid, a glycosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units. Sodium hyaluronate occurs as white to off-white powder or granules. It is very hygroscopic

    Chemical Name: Sodium hyaluronate

    Humectant; lubricant; sustained-release agent.

    • Sodium hyaluronate is the predominant form of hyaluronic acid at physiological pH.

    • The name hyaluronan is used when the polysaccharide is mentioned in general terms, and in the literature the terms hyaluronic acid and sodium hyaluronate are used interchangeably.

    • Hyaluronan is used therapeutically to treat osteoarthritis in the knee, and is an effective treatment for arthritic pain.

    • Crosslinked hyaluronan gels are used as drug delivery systems.

    • Hyaluronan is the most common negatively charged glycosaminoglycan in the human vitreous humor, and is known to interact with polymeric and liposomal DNA complexes, where hyaluronan solutions have been shown to decrease the cellular uptake of complexes.

    • This is useful for enhancing the availability and retention time of drugs administered to the eye.

    • It is immunoneutral, which makes it useful for the attachment of biomaterials for use in tissue engineering and drug delivery systems; it also has important applications in the fields of vascosurgery and vascosupplementation.

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    Sodium hyaluronate is used in cosmetics and in topical, parenteral, and ophthalmic pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material. Sodium hyaluronate has been reported to be an experimental teratogen

    Observe normal precautions appropriate to the circumstances and quantity of material handled. When heated to decomposition, sodium hyaluronate emits toxic fumes of Na2O.

    Hyaluronic acid.