Sesame Oil

Synonyms: Benne oil; gingelly oil; gingili oil; jinjili oil; Lipovol SES; sesami oleum raffinatum; teel oil.

Description: Refined sesame oil is a clear, pale-yellow colored liquid with a slight, pleasant odor and a bland taste. It solidifies to a soft mass at about 4C.

Chemical Name: Sesame oil

oleaginous vehicle; solvent.

• The major use of sesame oil in pharmaceutical formulations is as a solvent in the preparation of sustained-release intramuscular injections of steroids, such as estradiol valerate, hydroxyprogesterone caproate, testosterone enanthate, and nandrolone decanoate, or other oil-soluble drug substances, such as the decanoates or enanthate esters of fluphenazine.

• The disappearance of sesame oil from the injection site, following subcutaneous or intramuscular administration to pigs, has been reported to have a half-life of about 23 days.

• The in vitro drug release rates from oily depot formulations containing sesame oil intended for intra-articular administration have been reported.

• Sesame oil may be used as a solvent in the preparation of subcutaneous injections, oral capsules, rectal suppositories, and ophthalmic preparations; it may also be used in the formulation of suspensions and emulsions.

• Multipleemulsion formulations, in which sesame oil was one of the oil phases incorporated, have been investigated as a prolonged-release system for rifampicin; microemulsions containing sesame oil have been prepared for the transdermal delivery of ketoprofen.

• Sesame oil has also been included in self-microemulsifying drug delivery systems, and fast-disintegrating lyophilized dry emulsion tablets for oral administration.

• It has also been used in the preparation of liniments, pastes, ointments, and soaps.

• A sesame paste (tahini), composed of crushed sesame seeds in sesame oil, has been investigated as a novel suspending agent

Sesame oil may be saponified by alkali hydroxides.

Sesame oil is mainly used in intramuscular and subcutaneous injections; it should not be administered intravenously. It is also used in topical pharmaceutical formulations and consumed as an edible oil.

Observe normal precautions appropriate to the circumstances and quantity of material handled. Spillages of sesame oil are slippery and should be covered with an inert absorbent material prior to disposal.

Almond oil; canola oil; corn oil; cottonseed oil; peanut oil; soybean oil; sunflower oil.