Secukinumab

DEA Class; Rx

Common Brand Names; Cosentyx

• Interleukin Inhibitors; 
• Monoclonal Antibodies

Hypersensitivity

• Infections (29%)
• Diarrhea (4.1%)
• Upper respiratory tract infection (2.5%)
• Rhinitis (1.4%)
• Oral herpes (1.3%)
• Pharyngitis (1.2%)
• Rhinorrhea (1.2%)
• Infections (28.7%)
• Nasopharyngitis (11.4%)

May increase risk of infections; caution when considering use in patients with chronic infection or a history of recurrent infection

In the postmarketing setting, serious and some fatal infections reported; instruct patients to seek medical advice if signs or symptoms suggestive of an infection occur; if a patient develops a serious infection, monitor the patient closely and discontinue therapy until infection resolves

Evaluate patients for tuberculosis (TB) infection before initiating; do not administer with active TB; for latent TB, initiate anti-TB therapy prior to initiation of secukinumab in patients with a history of latent or active TB in whom an adequate course of treatment cannot be confirmed; monitor patients closely for signs and symptoms of active TB during and after treatment

May exacerbate Crohn disease

Anaphylaxis and cases of urticaria reported; if this occurs, discontinue secukinumab immediately and initiate anaphylaxis treatment

Caution if latex allergic; the removable cap on the Sensoready pen and prefilled syringe contains natural rubber

Use caution when prescribing drug to patients with inflammatory bowel disease; exacerbations, in some cases serious, reported in clinical trials in plaque psoriasis, psoriatic arthritis, ankylosing spondylitis and non-radiographic axial spondyloarthritis

Limited available human data regarding use in pregnant women are insufficient to inform a drug associated risk of adverse developmental outcomes

Unknown if excreted in human milk or absorbed systemically after ingestion; data are unavailable regarding effects on breastfed children or milk production

Secukinumab

lyophilized powder for reconstitution

• 150mg/vial

solution for injection

• 150mg/prefilled syringe
• 150mg/Sensoready pen