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Roxithromycin

    Roxithromycin (RULID) 150mg, 300mg Tablet Uses
    Brands

    Roxithromycin is a macrolide with antibacterial properties similar to that of Erythromycin.

    DAE Class; Rx

    Common Brand Names; RULID, ACTIROX, Forilin, Surlid

    Roxithromycin is a macrolide with antibacterial properties similar to that of Erythromycin. It is active against gram positive bacteria for example, staphylococci, streptococci, listeria, corynebacteria; gram negative bacteria for example gonococci, Hemophilus influenza, Hemophilus ducreyi, Legionella, and atypical pathogen, for example mycoplasma and chlamydia. Roxithromycin is well torelated by children and adults. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular interval of time throughout the day and night as prescribed. It is important to take the drug for the full time period as prescribed, discontinuation of the drug may result in ineffective treatment.

    Roxithromycin is primarily used in conditions like Ent infections, Genitourinary tract infections, Pneumonia, Skin infections.

    Upper respiratory tract infection: acute pharyngitis, tonsilitis and sinusiti.

    Lower respiratory tract infection: acute bronchitis and acute exacerbations of chronic bronchitis; community acquired pneumonia. Skin and skin structure infections.

    Dental infections

    Nongonococcal urethritis.

    Skin and skin structure infections

    Roxithromycin is contraindicated in conditions like Hepatic disease, Hypersensitivity.

    • known hypersensitivity to macrolides, including erythromycin
    • severely impaired hepatic function 
    • concomitant therapy with vasoconstrictive ergot alkaloids 

    The symptomatic side effects produced by Roxithromycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Diarrhea, Rashes, Nausea and vomiting, Elevated alkaline phosphatase, Epigastric pain, GI disturbance, Elevated SGPT & SGOT.

    Precaution should be taken in hepatic insufficiency, prenancy and lactation. It should be used with caution in patients with any allergy, especially to antibiotics. Take appropriate measures if secondary infection occurs.

    Drug should not be given to patients suffering from Kidney dysfunction.

    Use in the elderly: No dosage adjustment is required in elderly patients.

    Pregnancy (Category B1): The safety of roxithromycin for the human fetus has not been established

    Use in lactation: Small amounts of roxithromycin are excreted in the breast milk. Breastfeeding or treatment of the mother should be discontinued as necessary.

    Oral
    Acute bronchitis, Acute exacerbations of chronic bronchitis, Acute pharyngitis, Community-acquired pneumonia, Nongonococcal urethritis, Sinusitis, Skin and soft tissue infections, Tonsillitis

    Adult Dose: Recommended dose: 150 mg bid or 300 mg once daily for 5-10 days. Duration of treatment may be longer depending on the indication and clinical response.
     
    Child Dose:For children 40 kg and over
    One 150 mg tablet morning and evening.
    The usual duration of treatment is five to ten days depending on the indication and clinical response.
    Streptococcal throat infections require ten days of therapy. The duration of treatment should not exceed ten days.
     
    Special populations
    Elderly: 300 mg tablets: one tablet daily. 150 mg tablets: one tablet twice daily
    or two tablets once daily.
     
    Impaired renal function: 300 mg tablets: one tablet daily. 150 mg tablets: one tablet twice daily
    or two tablets once daily.
     
    Impaired hepatic function: One 150 mg tablet once daily for patients with documented cirrhotic liver disease.

    Roxithromycin dosage form and strenght

    Suspension: 50 mg/5ml,

    Tablets: 50 mg, 100 mg, 150 mg, 300 mg,

    Capsules: 150 mg, 300 mg,