Skip to content

Pyrazinamide

    Brands

    DEA Class; Rx

    Common Brand Names; Nydrazid

    • Antitubercular Agents

    Antituberculosis agent; useful when resistance to isoniazid or rifampin has been confirmed; used in combination with other agents.

    Indicated for the treatment of drug-susceptible tuberculosis infection as part of combination therapy.
    For the treatment of drug-resistant tuberculosis infection as part of combination therapy.
     

    Severe hepatic damage, acute gout, hypersensitivity

    • Malaise
    • Nausea
    • Vomiting
    • Anorexia
    • Arthralgia
    • Myalgia
    • <1%
    • Fever
    • Rash
    • Itching
    • Acne
    • Photosensitivity
    • Gout
    • Dysuria
    • Porphyria
    • Thrombocytopenia
    • Hepatotoxicity
    • Interstitial nephritis

    See pkg insert for complete dosage info

    Pregnancy Category: C

    Lactation: enters breast milk

    Dosing is based on lean body weight.

    Adults

    30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly are the FDA-approved maximum dosages. Other regimens and maximum dosages have been used off-label.
    Weighing more than 90 kg: 30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly.
    Weighing 76 to 90 kg: 2 g PO once daily or 5 days/week, 3 g PO 3 days/week, or 4 g PO twice weekly.
    Weighing 56 to 75 kg: 1.5 g PO once daily or 5 days/week, 2.5 g PO 3 days/week, or 3 g PO twice weekly.
    Weighing 40 to 55 kg: 1 g PO once daily or 5 days/week, 1.5 g PO 3 days/week, or 2 g PO twice weekly.

    Geriatric

    30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly are the FDA-approved maximum dosages. Other regimens and maximum dosages have been used off-label.
    Weighing more than 90 kg: 30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly.
    Weighing 76 to 90 kg: 2 g PO once daily or 5 days/week, 3 g PO 3 days/week, or 4 g PO twice weekly.
    Weighing 56 to 75 kg: 1.5 g PO once daily or 5 days/week, 2.5 g PO 3 days/week, or 3 g PO twice weekly.
    Weighing 40 to 55 kg: 1 g PO once daily or 5 days/week, 1.5 g PO 3 days/week, or 2 g PO twice weekly.

    Adolescents

    30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly are the FDA-approved maximum dosages. 40 mg/kg/dose (Max: 2 g/dose) PO once daily or 5 days/week or 50 mg/kg/dose PO 3 days/week (Max: 3 g/dose) or twice weekly (Max: 4 g/dose) have been used off-label.

    Children

    30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly are the FDA-approved maximum dosages. 40 mg/kg/dose (Max: 2 g/dose) PO once daily or 5 days/week or 50 mg/kg/dose PO 3 days/week (Max: 3 g/dose) or twice weekly (Max: 4 g/dose) have been used off-label.

    Infants

    30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly are the FDA-approved maximum dosages. 40 mg/kg/dose (Max: 2 g/dose) PO once daily or 5 days/week or 50 mg/kg/dose PO 3 days/week (Max: 3 g/dose) or twice weekly (Max: 4 g/dose) have been used off-label.

    Neonates

    Safety and efficacy have not been established. 40 mg/kg/dose PO once daily has been used off-label.

    Pyrazinamide

    tablet

    • 500mg