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Protriptyline

    Generic Only

    DEA Class;  Rx

    Common Brand Names; Pamelor, Aventyl

    • Antidepressants, TCAs

    Neurotransmitter (especially NE and serotonin) reuptake inhibitor; increases concentration of neurotransmitte in the central nervous system.

    Depression

    Hypersensitivity

    Severe cardiovascular disorder

    Narrow angle glaucoma

    Within 14 days of MAOIs (risk of serotonin syndrome); if linezolid or IV methylene blue (MAOIs) must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity; may resume 24 hr after last linezolid or methylene blue dose, or after 2 weeks of monitoring, whichever comes first

    Any drugs or conditions that prolong QT interval

    Acute recovery post-MI

    • Sedation
    • Fatigue
    • Headache
    • Agitation
    • Insomnia
    • Blurred vision
    • Weakness
    • Lethargy
    • Anxiety
    • Dry mouth
    • Constipation
    • Nausea
    • Vomiting
    • Sweating
    • Weight change
    • Confusion
    • EPS
    • Dizziness
    • Tinnitus
    • Paresthesia
    • Seizure (rare)
    • Worsening depression/suicide (rare)
    • Orthostatic hypotension
    • ECG changes
    • Tachycardia
    • Paralytic ileus (rare)
    • Agranulocytosis (rare)
    • Thrombocytopenia (rare)
    • Eosinophilia (rare)
    • Leukopenia (rare)
    • Increased LFTs
    • Sexual dysfunction
    • Rash
    • SIADH (rare)

    Caution in BPH, urinary/GI retention, hyperthyroidism, open-angle glaucoma, seizure disorder, brain tumor, respiratory impairment

    Clinical worsening and suicide ideation may occur despite medication

    Risk of anticholinergic side-effects

    Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy

    Pregnancy Category: C

    Lactation: avoid

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    Protriptyline Hcl