General Description
Synonyms: Alginic acid, propylene glycol ester; E405; hydroxypropyl alginate; Kelcoloid; Kimiloid; Manucol Ester; Profoam; Pronova; propane1,2-diol alginate; Protanal; TIC Pretested.
Description: Propylene glycol alginate occurs as a white to yellowish colored, practically odorless and tasteless, fibrous or granular powder.
Chemical Name: Propylene glycol alginate
Functions
Emulsifying agent; foam stabilizer; stabilizing agent; suspending agent; viscosity increasing agent.
Uses
Propylene glycol alginate is used as a stabilizing, suspending, gelling, and emulsifying agent in oral and topical pharmaceutical formulations.
Typically, a concentration of 0.3–5% w/v is used, although this may vary depending upon the specific application and the grade of propylene glycol alginate used.
Propylene glycol alginate is also used in cosmetics and food products.
Safety
Propylene glycol alginate is used in oral and topical pharmaceutical formulations, cosmetics, and food products. It is generally regarded as a nontoxic and nonirritant material, although excessive oral consumption may be harmful. A study in five healthy male volunteers fed a daily intake of 175 mg/kg body-weight of propylene glycol alginate for 7 days, followed by a daily intake of 200 mg/kg body-weight of propylene glycol alginate for a further 16 days, showed no significant adverse effect
Handling Precautions
Observe normal precautions appropriate to the circumstances and quantity of material handled. Propylene glycol alginate may be irritant to the eyes or respiratory system if inhaled as dust; see Section 14. Eye protection, gloves, and a dust respirator are recommended. Propylene glycol alginate should be handled in a well-ventilated environment
Related Substances
Alginic acid; propylene glycol; sodium alginate.