Prednisolone/Gentamicin Ophthalmic

DEA Class; Rx

Common Brand Names; Pred G

Indicated for Ocular Anti-inflammatory/Anti-infective.

For steroid-responsive inflammatory ocular inflammation conditions (e.g., uveitis, bacterial conjunctivitis, corneal abrasion) for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular/ophthalmic infection exists.

Hypersensivity to any component

Glaucoma, viral diseases of cornea & conjunctiva (epithelial herpes simplex keratitis, vaccinia, varicella), mycobacterial eye infection & fungal diseases of ocular structures

• Ocular discomfort
• Irritation upon instillation
• Punctate keratitis
• Elevation of IOP with possible development of glaucoma
• Optic nerve damage
• Posterior subcapsular cataract formation
• Delayed wound healing
• Secondary infection
• Fungal infections of the cornea
• Allergic sensitizations
• Rash
• Superinfection (herpes)
• Eye burning
• Eye stinging
• Ocular hyperemia
• Eye pain
• Eye discharge
• Lacrimation increased
• Eye edema
• Visual impairment
• Foreign body sensation in eyes
• Dysgeusia
• Blurry vision
• Hypersensitivity including signs and symptoms related to ocular allergy (e.g. conjunctivitis), angioedema (e.g. tongue edema) and allergic skin reactions (e.g. rash and contact allergy)

Bacterial keratitis reported from inadvertent contamination of multiple dose ophthalmic solution Immunosuppression resulting from prolonged use of steroid use may result in secondary bacterial and fungal infections; steroids may also mask symptoms of infections and enhance existing ocular infections

Ocular hypertension and/or glaucoma reported with prolonged corticosteroid use

Corticosteroid and gentamicin use following cataract surgery may delay healing

Discontinue use if sensitivity reaction to gentamicin develops

Prolonged gentmicin use may result in fungal or bacterial superinfection

Pregnancy: C

Lactation: Unknown whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk; systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause untoward effects