Polyoxylglycerides

Synonyms: 

Description: Polyoxylglycerides are inert liquid or semi-solid waxy materials and are amphiphilic in character. Caprylocaproyl polyoxylglycerides are pale-yellow oily liquids. Lauroyl polyoxylglycerides and stearoyl polyoxylglycerides occur as pale-yellow waxy solids. Oleoyl polyoxylglycerides and linoleoyl polyoxylglycerides occur as amber oily liquids, which may give rise to a deposit after prolonged periods at 20C.

Chemical Name: 

Dissolution enhancer; emulsifying agent; nonionic surfactant; penetration agent; solubilizing agent; sustained-release agent.

• Polyoxylglycerides are used as self-emulsifying and solubilizing agents in oral and topical pharmaceutical formulations.

• They are also used in cosmetic and food products.

—

Polyoxylglycerides are used in oral and topical pharmaceutical formulations, and also in cosmetics and food products. They are generally regarded as relatively nonirritant and nontoxic materials.

Observe normal precautions appropriate to the circumstances and quantities of the material handled (refer to manufacturers’ safety information). Polyoxylglycerides are heterogeneous. Owing to their composition and physical characteristics, semisolid polyoxylglycerides can segregate by molecular weight over time during storage in containers, resulting in a nonhomogenous distribution. In addition, semisolid polyoxylglycerides must be heated to at least 20C above melting point in order to ensure that all crystallization clusters are fully melted. Therefore, it is essential that the entire contents of each container are melted to facilitate sample withdrawal or transfer, ensuring sample homogeneity

—