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Poly(DL-Lactic Acid)

    Synonyms: DL-Dilactide homopolymer; DL-dilactide polymer; DL-PLA; DL-3,6- dimethyl-1,4-dioxane-2,5-dione homopolymer; DL-PLA; lactic acid homopolymer; D,L-lactic acid homopolymer; D,L-lactic acid polymer; D-lactic acid-L copolymer; DL-lactide polymer; D-lactide-Llactide copolymer; PDLLA; poly (RS)-2-hydroxypropanoic acid; D,L-polylactic acid; poly(dl-lactic acid); polylactide; poly(DL-lactide); poly-DL-lactide; RS-propanoic acid, 2-hydroxy-, homopolymer

    Description: Poly(DL-lactic acid) is a glassy material, occurring as white to golden-yellow pellets or granules.

    Chemical Name: Poly[oxy(1-methyl-2-oxo-1,2-ethanediyl)]

    Biodegradable material; coating agent; controlled-release agent.

    • Poly(DL-lactic acid) is used in drug delivery systems in implants, injections, and oral solid dispersions. It is also used as a coating agent.

    Incompatible with strong acids or alkaline materials.

    Poly(DL-lactic acid) degrades to produce lactic acid, which is considered a well-tolerated nontoxic material. Several in vitro and in vivo studies demonstrated that poly(lactic acid) in general (including poly(DL-lactic acid)) is well tolerated and does not induce a significant immune response.(6–10) However, some studies have illustrated signs of a mild immune response.

    Observe normal precautions appropriate to the circumstances and quantity of the material handled. Eye and skin protection are recommended. Handle under dry, inert conditions.

    Aliphatic polyesters; lactic acid.