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Pindolol

    Brands

    DEA Class;  Rx

    Common Brand Names; Visken

    • Beta-Blockers, Intrinsic Sympathomimetic

    Oral beta-blocker and angiotensin II receptor blocker (ARB)
    Used for the treatment of hOral, nonselective, beta-blocker; high degree of intrinsic sympathomimetic activity (ISA) (partial agonist activity); partial agonism is greater for beta-2 than beta-1 receptors, which may be associated with vasodilation; approved for HTN.ypertension
    Can be used in patients not adequately controlled on valsartan 80 mg or nebivolol up to and including 10 mg or in patients already receiving 5 mg nebivolol and 80 mg valsartan

    Indicated for the treatment of hypertension.

    For treatment of chronic stable angina

    Overt heart failure, asthma/COPD, cardiogenic shock, hypersensitivity, sinus bradycardia, 2nd-3rd degree heart block, cardiogenic shock, sick sinus syndrome without permanent pacemaker

    • Insomnia (10%)
    • Muscle pain (10%)
    • Dizziness (9%)
    • Fatigue (8%)
    • Nervousness (7%)
    • Elevated liver enzymes (7%)
    • Joint pain (7%)
    • Edema (6%)
    • Vivid dreams (5%),
    • Abdominal discomfort (4-5%)
    • Nausea (4-5%)
    • Muscle cramps (3%)
    • Paresthesias (3%)
    • Bradycardia (2%)
    • Cold extremities (2%)
    • Hypotension (2%)
    • Palpitations (2%)
    • Syncope (2%)
    • Tachycardia (2%)
    • Anxiety (2%)
    • Lethargy (2%)
    • Diarrhea (2%)
    • Vomiting (2%)
    • Impotence/reduced libido (1-2%)

    Use caution in anesthesia/surgery (myocardial depression), bronchospastic disease, cerebrovascular insufficiency, CHF, cardiomegaly, DM, hyperthyroidism/thyrotoxicosis, myasthenia gravis, liver disease, renal impairment, peripheral vascular disease, use in pheochromocytoma, IDDM, history of psychiatric disease, pre-existing sick sinus syndrome or similar cardiac conditions

    Chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery; the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures

    Sudden discontinuation can exacerbate angina and lead to myocardial infarction

    Less effective than thiazide diuretics in black and geriatric patients

    Increased risk of stroke after surgery

    Pregnancy Category: B

    Lactation: do not nurse

    Adults

    60 mg/day PO for hypertension; 40 mg/day PO for angina.

    Elderly

    60 mg/day PO for hypertension; 40 mg/day PO for angina.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    Pindolol

    tablets

    • 5mg
    • 10mg