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Phenoxybenzamine

    Brands

    DEA Class;  Rx

    Common Brand Names; Dibenzyline

    • Alpha Blockers, Antihypertensives

    Alpha-adrenergic antagonist; particularly effective in smooth muscle and exocrine glands
    Useful in the treatment of sweating and hypertension associated with pheochromocytoma and for certain peripheral vasospastic conditions

    Indicated For the treatment of excessive sweating and hypertension associated with pheochromocytoma.

    For the treatment of peripheral vasospastic disorders (e.g., Raynaud’s phenomenon, acrocyanosis, or frostbite).

    For the treatment of urinary symptoms associated with benign prostatic hyperplasia (BPH).
     

    Hypersensitivity to phenoxybenzamine

    Any conditions in which fall in BP is undesirable

    Orthostatic hypotension

    • Orthostatic hypotension
    • Tachycardia
    • Dizziness
    • Drowsiness
    • Fatigue
    • Malaise
    • Sedation
    • Dry mouth
    • Nausea
    • Vomiting
    • Inhibition of ejaculation
    • Miosis
    • Nasal congestion

    Cerebral or coronary arteriosclerosis, CHF, respiratory infection, renal impairment

    Concomitant use of drugs that stimulate alpha/beta receptors (may increase hypotension/tachycardia)

    May have carcinogenic potential

    Use caution in the elderly (increased risk of adverse effects)

    First dose effect may occur, causing a sudden and drastic fall in blood pressure after administering the first dose.

    Hypotension/syncope may occur with first few doses or with increase in dose

    Minimize by using small first dose at bedtime

    Increase dose slowly

    Pregnancy Category: C

    Lactation: Not known if excreted into breast milk, discontinue drug or do not nurse

    Adults

    Specific maximum dosage information is not available. Dosage should be based on efficacy and tolerance.

    Elderly

    Specific maximum dosage information is not available. Dosage should be based on efficacy and tolerance.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established, although doses up to 4 mg/kg/day PO have been used.

    Phenoxybenzamine hydrochloride

    capsule

    • 10mg