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Pentazocine/Naloxone

    Brands

    DEA Class; Rx

    Common Brand Names; Talwin NX

    • Analgesics, Opioid Combos; 
    • Analgesics, Opioid Partial Agonist

    Synthetic opiate agonist-antagonist analgesic combined with a semisynthetic opiate-receptor antagonist
    Formulation is intended to prevent pentazocine misuse and abuse
    One-sixth to one-third as potent as morphine

    Indicated for the treatment of moderate pain to severe pain for which alternative treatments are inadequate.

    Hypersensitivity

    Do not inject dissolved tablets

    If prescribed for long-term use, take precautions to avoid increases in dose by the patient

    increased intracranial pressure 
    seizures 
    toxic epidermal necrolysis 
    anaphylactic shock 
    angioedema 
    Stevens-Johnson syndrome 
    erythema multiforme 
    neonatal opioid withdrawal syndrome 
    serotonin syndrome 
    SIADH 

    —

    Pregnancy Category: C

    Lactation: use caution

    Adults

    600 mg/6 mg per day PO.

    Geriatric

    600 mg/6 mg per day PO.

    Adolescents

    600 mg/6 mg per day PO.

    Children

    12 years: 600 mg/6 mg per day PO.
    1 to 11 years: Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Neonates

    Safety and efficacy have not been established.

    Pentazocine/naloxone

    tablet: Schedule IV

    • 50mg/0.5mg