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Penicillin V

    Brands

    DEA Class; Rx

    Common Brand Names; Pen Vee K, Penicillin V, Veetids

    • Penicillins, Natural

    Naturally derived penicillin antibiotic. Preferred over penicillin G when oral administration is desired due to better gastric acid stability, which results in higher plasma levels. Amoxicillin is preferred over pencillin V in some clinical situations such as endocarditis prophylaxis.

    Indicated for Streptococcal Pharyngitis

    Indicated for Actinomycosis, Erysipelas, Periodontal Infections, Recurrent Rheumatic Fever

    Also indicated for Prosthetic Joint Infection (Off-label)

    Allergy to penicillins, cephalosporins, or imipenem

    Diarrhea

    Nausea

    Oral candidiasis

    Vomiting

    Seizure

    Anemia

    Interstitial nephritis

    Hypersensitivity

    Anaphylaxis

    Positive Coombs reaction

    Caution in severe renal impairment

    Prolonged use may result in superinfection

    Use with caution in patients with asthma history; IGE mediated anaphylactic reactions (eg, urticaria, anaphylaxis) reported

    Use with caution in neonates; some dosage forms may contain sodium benzoate/benzoic acid, which may cause fatal toxicity (gasping syndrome) when used in large amounts

    Adverse effects, including hemolytic anemia, serum sickness, or neutropenia, may occur with prolonged use; serum concentrations may increase with extended duration of therapy, especially in patients with renal insufficiency

    Use caution in patients with history of seizure disorders; high serum levels, especially in the presence of renal impairment, may increase risk of seizures

    Pregnancy

    Penicillin crosses the placenta; use during pregnancy generally has not resulted in an increased risk of fetal adverse effects

    Lactation

    Penicillin is excreted into breast milk; compatible with breastfeeding

    Adults

    2 g/day PO.

    Geriatric

    2 g/day PO.

    Adolescents

    2 g/day PO.

    Children

    12 years: 2 g/day PO.
    1 to 12 years: Safety and efficacy have not been established; however, doses up to 75 mg/kg/day (Max: 2 g/day) PO have been used off-label.

    Infants

    Safety and efficacy have not been established; however, doses up to 75 mg/kg/day PO have been used off-label.

    Neonates

    Safety and efficacy have not been established; however, doses up to 75 mg/kg/day PO have been used off-label.

    Penicillin V

    oral solution

    • 125mg/5mL
    • 250mg/5mL

    tablet

    • 250mg
    • 500mg