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Penicillin G Benzathine

    Brands

    DEA Class; Rx

    Common Brand Names; Bicillin LA, Permapen

    • Penicillins, Natural

    Repository form of penicillin for intramuscular use only; tissue depot allows slow drug absorption over several days; provides lower and prolonged serum concentrations compared to aqueous penicillin G; used in mild to moderate infections due to susceptible organisms, prophylaxis and treatment of rheumatic fever, syphilis.

    Indicated for Group A Streptococcal Respiratory Infections

    For the treatment of upper respiratory tract infections, including group A beta-hemolytic streptococcal (GAS) pharyngitis (primary rheumatic fever prophylaxis) and tonsillitis.
    Indicated for Rheumatic Fever Prophylaxis, Syphilis.
    For diphtheria carriage eradication.
     

    Hypersensitivity; serious and occasionally fatal reactions have been reported

    Skin rashes including maculopapular eruptions and exfoliative dermatitis

    Urticaria

    Serum-sicknesslike reactions (eg, chills, fever, edema, arthralgia, prostration)

    Jarisch-Herxheimer reaction reported when treating syphilis

    Pseudomembranous colitis

    For deep IM administration only; do not administer IV, SC, or IT

    Do not inject near nerve or artery

    Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP) reported in patients taking beta-lactam antibiotics; discontinue therapy when SCAR suspected; consider an alternative treatment

    Pseudomembranous colitis reported with antibacterial agents, including penicillin G

    Administer by deep intramuscular injection only in the upper, outer quadrant of buttock (dorsogluteal) or ventrogluteal site; quadriceps femoris fibrosis and atrophy reported following repeated intramuscular injections of penicillin preparations into anterolateral thigh and is not recommended

    Pregnancy Category: B

    Lactation: Excreted into breast milk, caution advised

    Adults

    2.4 million units/day IM.

    Geriatric

    2.4 million units/day IM.

    Adolescents

    50,000 units/kg/day IM (Max: 2.4 million units/day).

    Children

    50,000 units/kg/day IM (Max: 2.4 million units/day).

    Infants

    50,000 units/kg/day IM (Max: 600,0000 units/day).

    Neonates

    50,000 units/kg/day IM.

    Penicillin G benzathine

    injectable suspension

    • 600,000 units/1mL
    • 1.2 million units/2mL
    • 2.4 million units/4mL