Penicillin G Aqueous

DEA Class; Rx

Common Brand Names; Pfizerpen, penicillin G potassium, penicillin G sodium, Crystapen

Indicated for the treatment of bacteremia or empyema.

Allergy to penicillins, cephalosporins, imipenem

Seizure

Anemia

Interstitial nephritis

Hypersensitivity

Anaphylaxis

Jarisch-Herxheimer reaction

Positive Coombs’ reaction

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions reported; reactions likely to occur in individuals with a history of penicillin hypersensitivity and/or a history of sensitivity to multiple allergens; before initiating therapy, inquire about previous hypersensitivity reactions to penicillins, cephalosporins, or other allergens; discontinue and institute appropriate therapy If an allergic reaction occurs

Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP) reported when SCAR is suspected, discontinue therapy and consider an alternative treatment

The use of antibiotics may promote overgrowth of nonsusceptible organisms, including fungi; indwelling intravenous catheters encourage superinfections; should superinfection occur, appropriate measures should be taken; when indicated, incision and drainage or other surgical procedures should be performed in conjunction with antibiotic therapy

Care should be taken to avoid intravenous or accidental intraarterial administration, or injection into or near major peripheral nerves or blood vessels, since such injections may produce neurovascular damage; particular care should be taken with IV administration because of possibility of thrombophlebitis

Skipping doses or not completing the full course of therapy may decrease the effectiveness of the immediate treatment and increase the likelihood that bacteria will develop resistance and will not be treatable by Penicillin G Potassium for Injection, USP or other antibacterial drugs in the future

In renal/hepatic impairment, reduce dose based on severity of impairment

Pregnancy Category: B

Lactation: excreted in breast milk