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Pancuronium

    Brands

    DEA Class;  Rx

    Common Brand Names; Pavulon

    • Neuromuscular Blockers, Nondepolarizing
     

    Parenteral, long-acting, nondepolarizing, neuromuscular blocking agent
    Used for an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation
    Minimal histamine release; associated with tachycardia and hypertension due to vagolytic properties

    Indicated for neuromuscular blockade during mechanical ventilation in intensive care patients

    For neuromuscular blockade during surgery.

    For muscular relaxation during non-emergent endotracheal intubation and rapid-sequence intubation (RSI)

    For the prevention of shaking chills induced by therapeutic hypothermia after cardiac arrest.

    Lack of ventilatory support, neuromuscular disease

    Hypersensitive to drug &/or bromides

    • Slight elevation in pulse rate
    • Elevations in blood pressure
    • Excessive salivation
    • Excessive sweating (in children)
    • Transient rashes
    • Wheezing
    • Dose-related tachycardia
    • Histamine release (bronchospasm/hypotension)

    Additive/synergistic effects if administered with or following an opioid, sedative or anesthetic agent

    Use caution in patients with poor renal perfusion or severe renal disease, preexisting tachycardia

    Adequate ventilatory support mandatory, may experience resistance with >25% TBSA burns, may experience increased sensitivity with electrolyte disorders (hyperMg, hypoK, hypoCa)

    Severe anaphylactic reactions to neuromuscular blocking agents have been reported; these reactions have, in some cases, been life threatening and fatal; because of the potential severity of these reactions, the necessary precautions, such as the immediate availability of appropriate emergency treatment, should be taken

    Pregnancy Category: C

    Lactation: not known if excreted in breast milk; effect on nursing infant not known

    Specific maximum dosage information is not available. Dosage must be individualized based on clinical response.

    Rocuronium bromide

    injectable solution

    • 1mg/mL
    • 2mg/mL