Oxaprozin

DEA Class;  Rx

Common Brand Names; Daypro

 NSAIDs

Absolute: ASA allergy, CABG

Relative: bleeding disorder, duodenal/gastric/peptic ulcer, stomatitis, SLE, ulcerative colitis, upper GI disease, late pregnancy (may cause premature closure of ductus arteriosus)

Edema

Rash

Abdominal pain

Anorexia

Constipation

Diarrhea

Indigestion

Nausea/Vomiting

GI ulcer

Gross bleeding with perforation

Heartburn

Anemia

LFT’s increased

Tinnitus

Dysuria, Increased frequency of urination

Myocardial infarction (<2%)

Use caution in asthma (bronchial), CHF, fluid retention, cardiac disease, severe hepatic impairment, hypertension, renal impairment

Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include the elderly, or those with impaired renal function, hypovolemia, heart failure, liver dysfunction, salt depletion, and individuals taking diuretics, ACE inhibitors, or ARBs

Factors that increase risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants; or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status

May cause drowsiness, dizziness, blurred vision, and other neurologic effects, which may impair physical or mental abilities; discontinue use and perform ophthalmologic exam with blurred or diminished vision occur

Pregnancy

Use of NSAIDs can cause premature closure of fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment

Because of these risks, limit dose and duration of use between about 20 and 30 weeks of gestation, and avoid use at about 30 weeks of gestation and later in pregnancy

Lactation

Naproxen and diphenhydramine are excreted in human breast milk; effect on infant unknown; not recommended

Tablet

• 600mg