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Orphenadrine/Aspirin/Caffeine

    Brands

    DEA Class; Rx

    Common Brand Names; Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte

    Analgesics, Other Combos

    Oral combination of salicylate analgesic (aspirin), CNS stimulant (caffeine), and centrally acting muscle relaxant (orphenadrine)

    Used for acute pain of musculoskeletal disorders

    Orphenadrine has anticholinergic properties and is contraindicated in glaucoma and certain GI and urinary diseases

    Indicated for symptomatic relief of mild-to-moderate pain caused by acute musculoskeletal disorders as an adjunct to rest, physical therapy, and other measures

    Glaucoma

    Pyloric or duodenal obstruction

    Achalasia

    Prostatic hypertrophy or bladder neck obstructions

    Myasthenia gravis

    Hypersensitivity to orphenadrine, aspirin, or caffeine

    Tachycardia

    Palpitation

    Urinary hesitancy or retention

    Dry mouth

    Blurred vision

    Dilated pupils

    Increased intraocular tension

    Weakness

    Nausea

    Vomiting

    Headache

    Dizziness

    Constipation

    Drowsiness

    Urticaria (rare)

    Other dermatosis (rare)

    Confusion in elderly individuals (infrequent)

    Mild central excitation and occasional hallucinations

    Not recommended for use in patients with chicken pox, influenza, or flu symptoms; Reye syndrome may develop in individuals who have chicken pox, influenza, or flu symptoms; studies suggest association between Reye syndrome and use of medicines containing salicylate or aspirin

    May impair patient’s ability to engage in potentially hazardous activities (eg, operating machinery, driving a motor vehicle)

    Pregnancy; Use of NSAIDs can cause premature closure of fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment

    Lactation; Safety during lactation has not been established

    Adults

    3080 mg/day PO aspirin, 240 mg/day PO caffeine, and 200 mg/day PO orphenadrine.

    Geriatric

    3080 mg/day PO aspirin, 240 mg/day PO caffeine, and 200 mg/day PO orphenadrine.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    orphenadrine/aspirin/caffeine

    Tablet

    50mg/770mg/60mg