Octyldodecanol

Synonyms: Eutanol G PH; isoarachidyl alcohol; Jarcol 1-20; Jeecol ODD; octildodecanol; octyldodecanolum; 2-octyldodecyl alcohol; 2-octyl1-dodecanol; 2-octyldodecanol; Standamul G.

Description: Octyldodecanol occurs as a clear, colorless, or yellowish, oily liquid.

Chemical Name: Octyldodecanol

Emollient; emulsifying agent; lubricant; solvent; thickening agent.

• Octyldodecanol is widely used in cosmetics and pharmaceutical applications as an emulsifying and opacifying agent.

• It is primarily used in topical applications because of its lubricating and emollient properties.

• Octyldodecanol has been used in the preparation of oil/water microemulsions investigated as the vehicle for the dermal administration of drugs having no or low skin penetration.

• Octyldodecanol has also been evaluated as a solvent for naproxen when applied topically

• Studies of estimated permeability coefficient suggest that octyldodecanol could be a potential dermal permeation enhancer.

Octyldodecanol is generally compatible with most materials encountered in cosmetic and pharmaceutical formulations.

Octyldodecanol is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as nontoxic and nonirritant at the levels employed as an excipient. In acute oral toxicity studies in rats fed 5 g/kg of undiluted octyldodecanol, no deaths were observed. In an acute dermal toxicity study, intact and abraded skin sites of guinea pigs were treated with 3 g/kg of undiluted octyldodecanol under occlusive patches; no deaths occurred and no gross skin lesions were observed. Octyldodecanol caused either no ocular irritation or minimal, transient irritation in the eyes of rabbits. However, some sources describe undiluted octyldodecanol as an eye and severe skin irritant.

Observe normal precautions appropriate to the circumstances and quantity of material handled. When heated to decomposition, octyldodecanol emits acrid smoke and irritating fumes.

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