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Nystatin

    Brands

    DEA Class; Rx

    Common Brand Names; Mycostatin, Nilstat, Nyamyc, Nystat Rx, Nystatin Systemic, Nystex

    • Antifungals, Other; 
    • Antifungals, Systemic
    • Vaginal

    nystatin topical (Rx)

    Brand and Other Names: Mycostatin topical, Pediaderm AF, PediDri, Nystop
    • Classes: Antifungals, Topical

    Topical polyene antifungal antibiotic.
    Used in the treatment of oropharyngeal, cutaneous, mucocutaneous, and vulvovaginal candidiasis; not useful for systemic fungal infections.
    Adverse events tend to be minimal due to limited systemic absorption.

    Indicated for the treatment of

    • Oropharyngeal Candidiasis
    • Intestinal Candidiasis
    • Invasive Fungal Infections (Orphan)
    • Liposomal nystatin: Treatment of invasive fungal infections
    • Vaginal Candidiasis
    • Mucocutaneous Infection

    Hypersensitivity

    • Diarrhea
    • Nausea
    • Stomach pain
    • Vomiting
    • Contact dermatitis
    • Stevens-Johnson syndrome
    • Hypersensitivity reactions

    Not for use in systemic mycoses

    Discontinue therapy if irritation or sensitization observed during use

    Pregnancy category: C

    Lactation: Not known if excreted in breast milk; use caution

    Adults

    2.4 million units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

    Geriatric

    2.4 million units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

    Adolescents

    2.4 million units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

    Children

    2.4 million units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

    Infants

    800,000 units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

    Neonates

    Neonates: 800,000 units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.
    Premature Neonates: 400,000 units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

    Nystatin

    oral powder

    • 100,000units/g

    oral suspension

    • 100,000units/mL

    oral tablet

    • 500,000units

    capsule

    • 500,000units
    • 1,000,000units

    vaginal tablet

    • 100,000 units

    cream/ointment/powder

    • 100,000 units/g