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Nisoldipine

    Brands

    DEA Class; Rx

    Common Brand Names; Sular

    • Calcium Channel Blockers; 
    • Calcium Channel Blockers, Dihydropyridine
    •  
    Long-acting, oral, dihydropyridine calcium-channel blocker; similar to nifedipine, but has greater affinity and selectivity for vascular smooth muscle, produces 5-10 times greater peripheral vasodilation, and has a longer half-life allowing QD dosing; approved for HTN; off-label for angina; 10 mg nisoldipine as effective as amlodipine 5 mg as a once daily dose for HTN.

    Indicated for the treatment of hypertension.

    For the treatment of ischemic heart disease including variant angina (Prinzmetal’s angina) and stable angina pectoris.

    Hypersensitivity to nisoldipine or other calcium channel blockers

    • Peripheral edema (22%)
    • Dizziness (5%)
    • Palpitation (3%)
    • Vasodilation (4%)
    • Increased severity of angina (1.5%)
    • Nausea (2%)
    • Pharyngitis (5%)
    • Sinusitis (3%)
    • Gingival hyperplasia
    • Colitis
    • Anemia
    • Alopecia
    • Anorexia
    • Anxiety
    • Ischemia
    • Diabetes mellitus
    • Dyspepsia
    • Dysphagia

    Use caution in CHF, aortic stenosis, hypotension (initially or after dose increases), persistent progressive dermatologic reactions, exacerbation of angina (during initiation of treatment, after dose increased, beta blocker withdrawal), liver impairment

    Reflex tachycardia resulting in angina and/or MI in patients with obstructive coronary disease reported

    Peripheral edema may occur within 2-3 weeks of initiating therapy

    Hypotension with or without syncope is possible (particularly with severe aortic stenosis)

    Do not take with high fat meal or grapefruit products

    Start at lower dose with liver/kidney dysfunction, elderly

    Pregnancy Category: C

    Lactation: not known if excreted in breast milk, use caution

    Adults

    34 mg/day PO.

    Elderly

    34 mg/day PO.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    Nisoldipine

    tablet, extended-release (generic)

    • 8.5mg
    • 17mg
    • 20mg
    • 25.5mg
    • 30mg
    • 34mg
    • 40mg

    tablet, extended-release (Sular, new hydrogel ER formulation)

    • 8.5mg
    • 17mg
    • 34mg