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Neomycin/Polymyxin B/Bacitracin

    Brands

    DEA Class; Rx

    Common Brand Names; Neo-Polycin, Neosporin Original Ointment, Triple Antibiotic Ointment

    • Antibiotics, Ophthalmic Combos
    • Antibacterials, Topical

    Neomycin; polymyxin B; bacitracin are available in topical and ophthalmic forms to treat infections of the eyes and skin. Neomycin and polymyxin B are primarily active against gram-negative, aerobic bacteria, while bacitracin is active against gram-positive bacteria.

    Indicted for the treatment of superficial ophthalmic infection (e.g., bacterial conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, and blepharoconjunctivitis) caused by susceptible bacteria.
    For the prevention of skin and skin structure infections, including wound management for skin abrasion and minor burn wound infection.

    Hypersensivity to neomycin, polymyxin B, zinc bacitracin

    Glaucoma

    Viral diseases of cornea and conjunctiva (epithelial herpes simplex keratitis, vaccinia, varicella)

    Mycobacterial infection of eye & fungal diseases of ocular structures

    Use in eyes or over large areas of body

    Conjunctival edema

    Rash

    Allergic contact dermatitis

    Itching

    Failure to heal

    Swelling

    Irritation

    Allergic contact dermatitis (60%)

    Contamination of container may occur, causing bacterial keratitis; avoid contamination of product

    For external use only

    Prolonged use may result in overgrowth of nonsusceptible organisms including fungi; if superinfection occurs, appropriate measures should be initiated

    Bacterial resistance may develop; if purulent discharge, inflammation, or pain becomes aggravated, patient should discontinue use and consult a physician

    Allergic cross-reactions may occur which could prevent use of any or all of the following antibiotics for treatment of future infections: kanamycin, paromomycin, streptomycin, and possibly gentamicin

    Pregnancy Category: C

    Lacation: Excretion in breast milk unknown; caution

    Adults

    8 applications/day for up to 10 days for ophthalmic ointment; 3 applications/day for up to 7 days topically.

    Elderly

    8 applications/day for up to 10 days for ophthalmic ointment; 3 applications/day for up to 7 days topically.

    Adolescents

    Safety and efficacy have not been established for ophthalmic ointment; 3 applications/day for up to 7 days topically.

    Children

    >= 2 years: Safety and efficacy have not been established for ophthalmic ointment; 3 applications/day for up to 7 days topically.
    < 2 years: Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Neonates

    Safety and efficacy have not been established.

    Neomycin/polymyxin B/bacitracin ophthalmic

    ophthalmic ointment

    • 400 units/3.5mg/10,000 units/g

    Neomycin/polymyxin B/bacitracin topical

    topical cream/ointment

    • (3.5mg/5,000units/400units)/1gram