Neohesperidin Dihydrochalcone

Synonyms: Citrosa; 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)- phenyl-2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside; 3,5-dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propionyl]phenyl-2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside; E959; neohesperidin DC; neohesperidin DHC; neohesperidin dihydrochalconum; neohesperidine dihydrochalcone; NHDC; 1- propanone; 1-[4-[[2-O-6-deoxy-a-L-mannopyranosyl)-b-D-glycopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl); Sukor.

Description: Neohesperidin dihydrochalcone occurs as a white or yellowishwhite powder with an intensely sweet taste.

Chemical Name: 1-[4-[[2-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl] oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one

Flavor enhancer; sweetening agent.

• Neohesperidin dihydrochalcone is a synthetic intense sweetening agent approximately 1500–1800 times sweeter than sucrose and 20 times sweeter than saccharin.

• Structurally it is an analogue of neohesperidin, a flavanone that occurs naturally in Seville oranges (Citrus aurantium).

• Neohesperidin dihydrochalcone is used in pharmaceutical and food applications as a sweetening agent and flavor enhancer.

• The sweetness profile is characterized by a lingering sweet/menthol-like aftertaste.

• The typical level used in foods is 1–5 ppm although much higher levels may be used in certain applications such as chewing gum.

• Synergistic effects occur with other intense and bulk sweeteners such as acesulfame K, aspartame, polyols, and saccharin.

• In pharmaceutical applications, neohesperidin dihydrochalcone is useful in masking the unpleasant bitter taste of a number of drugs such as antacids, antibiotics, and vitamins.

• In antacid preparations, levels of 10–30 ppm result in improved palatability.

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Neohesperidin dihydrochalcone is accepted for use in food products either as a sweetener or flavor modifier in a number of areas including Europe, USA, Australia, New Zealand, and several countries in Africa and Asia. It is also used in a number of oral pharmaceutical formulations. Animal toxicity studies suggest that neohesperidin dihydrochalcone is a nontoxic, nonteratogenic, and noncarcinogenic material at the levels used in foods and pharmaceuticals.

Observe normal precautions appropriate to the circumstances and quantity of material handled.

Lauric acid; myristic acid; palmitic acid; potassium myristate; sodium myristate; stearic acid.