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Naphazoline/Zinc Sulfate/Glycerin

    DEA Class; OTC

    Common Brand Names; Clear Eyes Cooling Comfort Itchy Eye Relief

    •  Decongestants, Ophthalmic

    Naphazoline: May stimulate a-adrenergic receptors of the sympathetic nervous system; may produce mydriasis when applied to the conjunctiva, but this effect is usually minimal with the concentrations used as ocular decongestants

    Zinc sulfate: Astringent

    Glycerin: Lubricant

    Temporary relief of ocular redness caused by irritation and relief of burning or irritation caused by dry eyes

    Do not use with MAO inhibitors

    Narrow angle glaucoma


    Stop use if vision changes, eye pain, condition worsens

    Blurred vision

    Mild transient stinging and/or irritation


    Increased or decreased intraocular pressure


    Use with caution in patients with hypertension, cardiovascular abnormalities, diabetes mellitus, hyperthyroidism, infection, or injury

    Rare reports of hypertension, cardiac irregularities, nervousness, nausea, dizziness, weakness, and sweating

    Pregnancy Category: C

    Lactation: not known if distributed in milk

    Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs


    1-2 gtt to affected eye q3-4hr up to QID PRN

    Not to exceed 72 hours of use


    1-2 gtt to affected eye q3-4hr up to QID PRN

    Not to exceed 72 hours of use

    Naphazoline/zinc sulfate/glycerin

    ophthalmic solution

    • 0.012%/0.25%/0.25%