Skip to content

Naftifine

    Brands

    DEA Class; Rx

    Common Brand Names; Naftin

    • Antifungals, Topical

    Topical allylamine antifungal
    Indicated for the interdigital tinea pedis, tinea cruris, and tinea corporis
    Similar efficacy and adverse events profiles to topical azole antifungals

    Indications

    • 1% cream: Indicated for treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum
    • 1% gel: Indicated for treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton Tonsurans, and Epidermophyton floccosum
    • 2% cream or gel: Indicated for treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum

    Hypersensitivity

    Transient burning/stinging (5-6%)

    Skin tenderness (0.5-3%)

    Dryness

    Erythema

    Pruritus

    Local irritation

    Rash

    Avoid use of occlusive dressings or wrappings

    Keep the cream away from eyes, nose, mouth, & other mucous membranes

    Reevaluate dx if no improvement after 4 wk

    Discontinue treatment if irritation or sensitivity develops with use; direct patients to contact their physician if these conditions develop

    Pregnancy: There are no available data in pregnant women to inform the drug-associated risk for major birth defects and miscarriage

    Lactation: There is no information available on presence of drug in human milk, effects of drug on breastfed infant, or effects of drug on milk production

    Adults

    No maximum dosage information is available.

    Geriatric

    No maximum dosage information is available.

    Adolescents

    No maximum dosage information is available for the 2% gel or 2% cream; safety and efficacy have not been established for all other formulations.

    Children

    12 years: No maximum dosage information is available for the 2% gel or 2% cream; safety and efficacy have not been established for all other formulations.
    2 to 11 years: No maximum dosage information is available for the 2% cream; safety and efficacy have not been established for all other formulations
    < 2 years: Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Neonates

    Safety and efficacy have not been established.

    Naftifine hydrochloride

    topical cream

    • 1%
    • 2%

    topical gel

    • 1%
    • 2%