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Nadolol

    Brands

    DEA Class;  Rx

    Common Brand Names; Corgard

    • Beta-Blockers, Nonselective

    Oral, long-acting, nonselective, beta-blocker; lacks appreciable intrinsic sympathomimetic or membrane-stabilizing activities; hydrophilic and renally eliminated.

    Indicated for the long-term management of angina pectoris.

    For the treatment of hypertension, either alone or in combination with other antihypertensive agents, especially thiazide diuretics.
    For ventricular tachycardia prophylaxis.
    For heart rate control in patients with atrial fibrillation or atrial flutter.
    For paroxysmal supraventricular tachycardia (PSVT) prophylaxis in patients with recurrent PSVT due to AV reentry.
    For migraine prophylaxis.
    For the treatment of portal hypertension and/or variceal bleeding prophylaxis in patients with esophageal varices.
    For the treatment of anxiety.
    For the treatment of thyrotoxicosis.
     

    Hypersensitivity

    2°/3° heart block

    Bronchial asthma

    Sinus bradycardia

    Cardiogenic shock

    Overt cardiac failure

    • Drowsiness
    • Insomnia
    • Decreased sexual ability
    • Bradycardia (2%)
    • Dizziness (2%)
    • Fatigue (2%)
    • Hypotension (1%)
    • Abdominal discomfort
    • Constipation
    • Diarrhea
    • Nausea
    • Cough
    • Nasal congestion
    • Bronchospasm, depression, decreased exercise tolerance, Raynaud’s phenomenon
    • May increase triglyceride levels and insulin resistance, and decrease HDL levels

    Anesthesia/surgery (myocardial depression); chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery, however the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures

    Use caution in cerebrovascular insufficiency, well-compensated CHF, liver disease, renal impairment, peripheral vascular disease

    Use caution in nonallergic bronchospasm; may block bronchodilation produced by endogenous or exogenous catecholamine stimulation of beta receptors

    Beta-adrenergic blockade may prevent appearance of premonitory signs and symptoms (eg, tachycardia and blood pressure changes) of acute hypoglycemia; this is especially important with labile diabetics; beta-blockade also reduces release of insulin in response to hyperglycemia; dose adjustment of antidiabetic drugs may be necessary

    Pregnancy Category: C

    Lactation: concentrated in breast milk, use caution (AAP Committee states compatible w/ nursing)

    Adults

    320 mg/day PO for hypertension; 240 mg/day PO for angina.

    Elderly

    320 mg/day PO for hypertension; 240 mg/day PO for angina.

    Adolescents

    No specific maximum dosage information is available.

    Children

    2.5 mg/kg/day PO for paroxysmal supraventricular tachycardia (PSVT) prophylaxis.

    Nadolol

    tablet

    • 20mg
    • 40mg
    • 80mg