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Miglitol

    Brands

    DEA Class; Rx

    Common Brand Names; Glyset

    • Antidiabetics, Alpha-Glucosidase Inhibitors

    Oral alpha-glucosidase inhibitor; in contrast to acarbose, miglitol is systemically absorbed before acting in GI tract
    Used for the treatment of type 2 diabetes mellitus
    Agents in this class have only modest effects on A1C (i.e., mean 0.3% to 0.7% reduction)

    Indicated for the treatment of type 2 diabetes mellitus as an adjunct to diet and exercise.

    Hypersensitivity to miglitol

    Diabetic ketoacidosis, inflammatory bowel disease, colonic ulceration, partial intestinal obstruction

    Disorders of GI digestion or absorption

    Conditions that may deteriorate due to increased GI gas

    Severe renal impairment

    Flatulence (42%)

    Diarrhea (29%)

    Abdominal pain (12%)

    Rash (4.3%)

    Low serum iron

    Concurrent use with sulfonylureas may result in hypoglycemia; treat hypoglycemia with oral glucose, not sucrose

    Pregnancy Category: B

    Lactation: Enters slightly into breast milk; nor recommended

    Adults

    300 mg/day PO.

    Geriatric

    300 mg/day PO.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy not been established.

    Miglitol

    tablet

    • 25mg
    • 50mg
    • 100mg