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Meclizine

    Brands

    DEA Class; OTC

    Common Brand Names; Antivert, Bonine, Meni D, meclozine, Dramamine Less Drowsy Formula, VertiCalm

    • Antiemetic Agents; 
    • Antiemetics, Antihistamine

    Oral piperazine-derivative sedating antihistamine; structurally similar to hydroxyzine
    Used primarily as an antivertigo and antiemetic agent for symptoms associated with motion sickness
    Has also been used medically in the management of vertigo in diseases affecting the vestibular apparatus

    Indicated for the treatment of nausea/vomiting and dizziness associated with motion sickness.

    For control of vertigo associated with vestibular system diseases.

    Hypersensitivity

    • Drowsiness
    • Thickening of bronchial secretions
    • Acute glaucoma attack
    • Blurred vision (rare)
    • Constipation
    • Fatigue
    • Vomiting
    • Xerostomia
    • Headache
    • Dry mouth
    • Urinary retention

    Use cautioin in obstructive genitourinary tract disease, asthma, pyloric or duodenal obstruction, prostatic hyperplasia, narrow angle glaucoma

    Hepatic impairment may increase meclizine systemic exposure

    Renal impairment may increase meclizine or metabolite accumulation

    May impair physical or mental abilities; use caution when operating heavy machinery or performing tasks which require mental alertness

    Pregnancy category: B

    Lactation: Not known if excreted in milk; use caution

    Adults

    100 mg/day PO for vertigo; 50 mg/day PO for nausea, vomiting, or dizziness associated with motion sickness.

    Geriatric

    100 mg/day PO for vertigo; 50 mg/day PO for nausea, vomiting, or dizziness associated with motion sickness.

    Adolescents

    50 mg/day PO for nausea, vomiting, or dizziness associated with motion sickness.

    Children

    12 years: 50 mg/day PO for nausea, vomiting, or dizziness associated with motion sickness.
    Less than 12 years: Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Neonates

    Safety and efficacy have not been established.

    Meclizine hydrochloride

    tablet

    • 12.5mg
    • 25mg
    • 32mg

    tablet, chewable

    • 25mg