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Maprotiline

    Brands

    DEA Class;  Rx

    Common Brand Names; Ludiomil

    • Antidepressants, TCAs

    Tetracyclic antidepressant of dibenzo-bicyclo-octadiene derivation; efficacy is similar to the TCAs for depression; occasionally administered for other indications.

    Indicated for the treatment of major depression.

    Hypersensitivity

    Severe cardiovascular disorders

    Narrow angle glaucoma

    Within 14 days of MAO inhibitors may cause serotonin syndrome

    Any drugs or conditions that prolong QT interval

    Acute recovery post-MI

    Common

    • Fatigue

    • Sedation

    • Lethargy

    • Weakness

    • Constipation

    • Dry mouth

    • Blurred vision

    Less Common

    • Agitation

    • Anxiety

    • Headache

    • Insomnia

    • Nausea

    • Vomiting

    • Sweating

    Infrequent

    • Orthostatic hypotension, ECG changes, tachycardia

    • Confusion, EPS, dizziness, paresthesia, tinnitus

    • Rash

    • Incr LFTs

    • Sexual dysfunction

    Rare

    • Seizure

    • Agranulocytosis

    • Thrombocytopenia

    • Eosinophilia

    • Leukopenia

    • SIADH

    Caution in BPH, urinary/GI retention, increased IOP, hyperthyroidism, open-angle glaucoma, seizure disorder, brain tumor, respiratory impairment

    Clinical worsening & suicide ideation may occur despite medication in adolescents & young adults (18-24 years)

    Risk of anticholinergic side-effects

    May cause sedation (may impair physical and mental abilities), orthostatic hypotension, and anticholinergic effects

    Pregnancy Category: B

    Lactation: avoid during breastfeeding

    Adults

    225 mg/day PO.

    Geriatric

    225 mg/day PO.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    Maprotiline hydrochloride

    tablet

    • 25mg
    • 50mg
    • 75mg