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Manganese

    Brands

    DEA Class; OTC

    Common Brand Names; MnCl2

    • Trace Elements/Metals

    Cofactor in many enzymes, incl superoxide dismutase (SOD, an antioxidant)

    Necessary for glycemic control, energy metabolism, thyroid hormone function

    May enhance bone turnover, cartilage synthesis

    Copper is indicated as

    • Dietary Supplement

    • Osteoporosis (Off-label)

    Direct IV/IM injection administration (must dilute)

    Not well documented

     

    May cause tissue damage if administered IV or IM directly due to very acidic solution (pH 2.0)

    Injection contains aluminum; use caution in renal impairment and premature infants

    Use caution in liver/biliary tract dysfunction, renal impairment (may need to decrease or withhold dose)

    Pregnancy Category: inj: C

    Lactation: Use caution

    Adequate Intake

    Male: 1.9-2.3 mg/day

    Female: 1.6-1.8 mg/day

    Pregnancy: 2 mg/day

    Lactation: 2.6 mg/day

    Prevention of Deficiency

    Parenteral solution (TPN):150-800 mcg/day IV

    Adequate Intake

    <6 months: 0.3-0.6 mg/day

    6-12 months: 0.6-1.0 mg/day

    1-3 years: 1.0-1.5 mg/day

    3-8 years: 1.5-2.0 mg/day

    8-13 years: 1.9 mg/day (males); 1.6 mg/day (females)

    13-18 years: 2.2 mg/day (males); 1.6 mg/day (females)

    Manganese

    Tablet

    • 10mg (elemental)
    • 15mg (elemental)
    • 93mg (aspartate; 25mg elemental)
    • 50mg (gluconate; 5.7mg elemental)

    Capsule

    • 16.67mg

    Injectable solution

    • 0.1mg/mL