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Macrogol 15 Hydroxystearate

    Synonyms:12-Hydroxyoctadecanoic acid polymer with a-hydro-o-hydroxypoly(oxy-1,2-ethanediyl); 12-hydroxystearic acid polyethylene glycol copolymer; macrogoli 15 hydroxystearas; polyethylene glycol15-hydroxystearate; polyethylene glycol 660 12-hydroxystearate;
    Solutol HS 15.

    Description: Macrogol 15 hydroxystearate is a yellowish-white, almost odorless waxy mass or paste at room temperature, which becomes liquid at approximately 30C.

    Chemical Name: 2-Hydroxyethyl-12-hydroxyoctadecanoate

    Dissolution enhancer; nonionic surfactant; solubilizing agent; stabilizing agent

    • Macrogol 15 hydroxystearate is frequently used in preclinical testing of drugs, mainly for IV and other parenteral applications.

    • The solubilizing capacity for some tested drugs (clotrimazole, carbamazepine, 17b-estradiol, sulfathiazole, and piroxicam) increases almost linearly with increasing concentration of solubilizing agent.

    • This is due to the formation of spherical micelles even at high concentrations of macrogol 15 hydroxystearate.

    • Similarly, tests have revealed that viscosity increases with increasing amount of solubilizer, but the amount of solubilized drugs does not have any additional influence on the kinematic viscosity.

    • Lipid nanocapsules comprising macrogol 15 hydroxystearate and soybean phosphatidylcholine containing 3% docetaxel have been successfully prepared by a solvent-free inversion process.

    • Macrogol 15 hydroxystearate has been used in the manufacture of aqueous parenteral preparations with vitamin A, D, E and K, and a number of other lipophilic pharmaceutical active agents, such as propanidid, miconazole, alfadolone, and alfaxalone.

    • It is very efficient at solubilizing substances like fat-soluble vitamins and active ingredients of hydrophobic nature.

    • It is also an excellent solubilizer for parenteral use, at a concentration of 20%, and the water solubility of different drugs may be enhanced by a factor of 10–100, depending on the structure of the drug molecule.

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    Macrogol 15 hydroxystearate is used in parenteral pharmaceutical preparations in concentrations up to 50% to solubilize diclofenac, propanidid, and vitamin K1. It has also been used in preclinical formulations in preparing supersaturated injectable formulations of water-insoluble molecules. It is generally regarded as a relatively nontoxic and nonirritant excipient.

    Observe normal precautions appropriate to the circumstances and quantity of material handled.

    Polyethylene glycol.