Lincomycin

DEA Class; Rx

Common Brand Names; Lincocin

• Antibiotics, Lincosamide

Lincosamide antibiotic
Used for serious staphylococcal, pneumococcal, and streptococcal infections in penicillin-allergic patients when other less toxic agents not appropriate Associated with pseudomembranous colitis

For the treatment of serious or severe infections (e.g., bacteremia) due to susceptible strains of streptococci, pneumococci, and staphylococci.

For subconjunctival injection during ocular surgery. Subconjunctival injection dosage Adults

Other Indications & Uses

Streptococcus pneumoniae & other streptococci

Hypersensitivity to lincomycin or clindamycin

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Tenesmus
• Glossitis
• Stomatitis
• Pruritus
• Angioedema
• Serum sickness and anaphylactic or anaphylactoid reactions
• Rash
• Urticaria
• Vaginitis
• Exfoliative/vesiculobullous dermatitis
• Erythema multiforme
• Thrombophlebitis
• Erythema
• Pain
• Swelling
• Transient increases in serum bilirubin, alkaline phosphatase, & AST (SGOT) concentrations
• Jaundice
• Transient leukopenia, neutropenia, eosinophilia
• Thrombocytopenia
• Agranulocytosis
• Headache
• Myalgia
• Tinnitus
• Dizziness
• Vertigo

Not for gram-positive bacteria

Use caution in patients with history of GI disease (colitis), asthma or allergies

Discontinue if persistent diarrhea occurs

Clostridioides difficile associated diarrhea (CDAD) reported with use of nearly all antibacterial agents, including this drug, and may range in severity from mild diarrhea to fatal colitis; careful medical history is necessary since CDAD has been reported to occur over two months after administration of antibacterial agents

Review of experience to date suggests that a subgroup of older patients with associated severe illness may tolerate diarrhea less well; when drug is indicated in these patients, they should be carefully monitored for change in bowel frequency

Prescribe with caution in individuals with a history of gastrointestinal disease, particularly colitis

Pregnancy

There are no adequate and well-controlled studies in pregnant women; sterile Solution contains benzyl alcohol as a preservative; benzyl alcohol can cross placenta; should be used during pregnancy only if clearly needed; experience with obstetrical patients receiving drug revealed no ill effects related to pregnancy

Lactation

Drug has been reported to appear in human milk in concentrations of 0.5 to 2.4 mcg/mL; because of potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing, or to discontinue drug, taking into account importance of drug to mother

Lincomycin Hydrochloride

Injectable solution

• 300mg/mL